1E66

STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-HUPRINE X AT 2.1A RESOLUTION

Summary for 1E66

Related3ACE 2DFP 2ACE 2ACK 1VXO 1VXR 1VOT 1SOM 1QTI 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QID 1QIE 1QIF 1OCE 1FSS 1EVE 1EEA 1DX6 1CFJ 1AX9 1AMN 1E3Q 4ACE 1ACJ 1ACL
DescriptorACETYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, 3-CHLORO-9-ETHYL-6,7,8,9,10,11-HEXAHYDRO-7,11-METHANOCYCLOOCTA[B]QUINOLIN-12-AMINE, ... (4 entities in total)
Functional Keywordscholinesterase, huprine x, alzheimer's disease, chemical hybrid, hydrolase
Biological sourceTORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
Total number of polymer chains1
Total molecular weight62066.32
Authors
Dvir, H.,Harel, M.,Silman, I.,Sussman, J.L. (deposition date: 2000-08-08, release date: 2001-08-02, Last modification date: 2019-04-03)
Primary citation
Dvir, H.,Wong, D.M.,Harel, M.,Barril, X.,Orozco, M.,Luque, F.J.,Munoz-Torrero, D.,Camps, P.,Rosenberry, T.L.,Silman, I.,Sussman, J.L.
3D Structure of Torpedo Californica Acetylcholinesterase Complexed with Huprine X at 2. 1 A Resolution: Kinetic and Molecular Dynamic Correlates.
Biochemistry, 41:2970-, 2002
PubMed: 11863435 (PDB entries with the same primary citation)
DOI: 10.1021/BI011652I
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.202100 2.1% 2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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