2BUB

Crystal Structure Of Human Dipeptidyl Peptidase IV (CD26) in Complex with a Reversed Amide Inhibitor

Summary for 2BUB

• Entry DOI: 10.2210/pdb2bub/pdb
• Related: 1J2E 1N1M 1NU6 1NU8 1PFQ 1R9M 1R9N 1RWQ 1TK3 1TKR 1U8E 1W1I 1WCY 1X70 2AJL 2BGN 2BGR
• Descriptor: DIPEPTIDYL PEPTIDASE 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE, ... (4 entities in total)
• Functional Keywords: hydrolase/inhibitor, complex (hydrolase-inhibitor), dpp-iv, diabetes mellitus, drug design, hydrolase, serine protease, aminopeptidase, glycoprotein, protease, signal-anchor, transmembrane, complex, hydrolase-inhibitor complex
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 171461.82

Authors

Nordhoff, S.,Cerezo-Galvez, S.,Feurer, A.,Hill, O.,Matassa, V.G.,Metz, G.,Rummey, C.,Thiemann, M.,Edwards, P.J. (deposition date: 2005-06-09, release date: 2006-01-23, Last modification date: 2020-07-29)

• Primary citation: Nordhoff, S.,Cerezo-Galvez, S.,Feurer, A.,Hill, O.,Matassa, V.G.,Metz, G.,Rummey, C.,Thiemann, M.,Edwards, P.J.; The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.; Bioorg. Med. Chem. Lett., 16:1744-1748, 2006; PubMed: 16376544; DOI: 10.1016/j.bmcl.2005.11.103

Experimental method

X-RAY DIFFRACTION (2.66 Å)