2AJL
X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor
Summary for 2AJL
Entry DOI | 10.2210/pdb2ajl/pdb |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE, ... (4 entities in total) |
Functional Keywords | aminopeptidase, hydrolase, protease, serine protease |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 172669.01 |
Authors | Qiao, L.,Baumann, C.A.,Crysler, C.S.,Ninan, N.S.,Abad, M.C.,Spurlino, J.C.,DesJarlais, R.L.,Kervinen, J.,Neeper, M.P.,Bayoumy, S.S. (deposition date: 2005-08-02, release date: 2005-11-08, Last modification date: 2023-08-23) |
Primary citation | Qiao, L.,Baumann, C.A.,Crysler, C.S.,Ninan, N.S.,Abad, M.C.,Spurlino, J.C.,Desjarlais, R.L.,Kervinen, J.,Neeper, M.P.,Bayoumy, S.S.,Williams, R.,Deckman, I.C.,Dasgupta, M.,Reed, R.L.,Huebert, N.D.,Tomczuk, B.E.,Moriarty, K.J. Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors Bioorg.Med.Chem.Lett., 16:123-128, 2006 Cited by PubMed: 16236500DOI: 10.1016/j.bmcl.2005.09.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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