2AJL

X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor

Summary for 2AJL

Entry DOI	10.2210/pdb2ajl/pdb
Descriptor	Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE, ... (4 entities in total)
Functional Keywords	aminopeptidase, hydrolase, protease, serine protease
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	172669.01
Authors	Qiao, L.,Baumann, C.A.,Crysler, C.S.,Ninan, N.S.,Abad, M.C.,Spurlino, J.C.,DesJarlais, R.L.,Kervinen, J.,Neeper, M.P.,Bayoumy, S.S. (deposition date: 2005-08-02, release date: 2005-11-08, Last modification date: 2023-08-23)
Primary citation	Qiao, L.,Baumann, C.A.,Crysler, C.S.,Ninan, N.S.,Abad, M.C.,Spurlino, J.C.,Desjarlais, R.L.,Kervinen, J.,Neeper, M.P.,Bayoumy, S.S.,Williams, R.,Deckman, I.C.,Dasgupta, M.,Reed, R.L.,Huebert, N.D.,Tomczuk, B.E.,Moriarty, K.J. Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors Bioorg.Med.Chem.Lett., 16:123-128, 2006 Cited by PubMed: 16236500 DOI: 10.1016/j.bmcl.2005.09.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation