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1RWQ

Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine

Summary for 1RWQ
Entry DOI10.2210/pdb1rwq/pdb
Related1NU6 1NU8
DescriptorDipeptidyl peptidase IV, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(AMINOMETHYL)-6-(2,4-DICHLOROPHENYL)-2-(3,5-DIMETHOXYPHENYL)PYRIMIDIN-4-AMINE, ... (4 entities in total)
Functional Keywordsdipeptidyl peptidase iv, exopeptidase, adenosine binding, drug design, complex structure, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight171505.45
Authors
Hennig, M.,Thoma, R.,Stihle, M. (deposition date: 2003-12-17, release date: 2004-12-17, Last modification date: 2020-07-29)
Primary citationPeters, J.U.,Weber, S.,Kritter, S.,Weiss, P.,Wallier, A.,Boehringer, M.,Hennig, M.,Kuhn, B.,Loeffler, B.M.
Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents
Bioorg.Med.Chem.Lett., 14:1491-1493, 2004
Cited by
PubMed: 15006388
DOI: 10.1016/j.bmcl.2004.01.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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