1TKR

Human Dipeptidyl Peptidase IV/CD26 inhibited with Diisopropyl FluoroPhosphate

Summary for 1TKR

Entry DOI	10.2210/pdb1tkr/pdb
Related	1TK3 1TO7
Descriptor	Dipeptidyl peptidase IV, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	alpha/beta hydrolase, beta-propeller, homodimer, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	174868.82
Authors	Bjelke, J.R.,Christensen, J.,Branner, S.,Wagtmann, N.,Olsen, C.,Kanstrup, A.B.,Rasmussen, H.B. (deposition date: 2004-06-09, release date: 2004-07-06, Last modification date: 2020-07-29)
Primary citation	Bjelke, J.R.,Christensen, J.,Branner, S.,Wagtmann, N.,Olsen, C.,Kanstrup, A.B.,Rasmussen, H.B. Tyrosine 547 Constitutes an Essential Part of the Catalytic Mechanism of Dipeptidyl Peptidase IV J.Biol.Chem., 279:34691-34697, 2004 Cited by PubMed: 15175333 DOI: 10.1074/jbc.M405400200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation