2BOH
Crystal structure of factor Xa in complex with compound "1"
2BOH の概要
エントリーDOI | 10.2210/pdb2boh/pdb |
関連するPDBエントリー | 1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1KYE 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1MSX 1NFU 1NFW 1NFX 1NFY 1NL8 1P0S 1V3X 1XKA 1XKB 2BMG |
分子名称 | COAGULATION FACTOR XA, CALCIUM ION, 1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE, ... (5 entities in total) |
機能のキーワード | hydrolase/inhibitor, complex (hydrolase-inhibitor), protein-inhibitor complex, blood coagulation factor, serine proteinase, rational drug design, calcium-binding, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, plasma, polymorphism, protease, serine protease, vitamin k, zymogen, hydrolase-inhibitor complex |
由来する生物種 | HOMO SAPIENS (HUMAN) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 44284.49 |
構造登録者 | Nazare, M.,Will, D.W.,Matter, H.,Schreuder, H.,Ritter, K.,Urmann, M.,Essrich, M.,Bauer, A.,Wagner, M.,Czech, J.,Laux, V.,Wehner, V. (登録日: 2005-04-11, 公開日: 2006-04-05, 最終更新日: 2023-12-13) |
主引用文献 | Nazare, M.,Will, D.W.,Matter, H.,Schreuder, H.,Ritter, K.,Urmann, M.,Essrich, M.,Bauer, A.,Wagner, M.,Czech, J.,Lorenz, M.,Laux, V.,Wehner, V. Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-Ray Crystallography. J.Med.Chem., 48:4511-, 2005 Cited by PubMed: 15999990DOI: 10.1021/JM0490540 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
構造検証レポート
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