2C5L

Structure of PLC epsilon Ras association domain with hRas

Summary for 2C5L

• Entry DOI: 10.2210/pdb2c5l/pdb
• Related: 121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 221P 2GDP 2Q21 421P 4Q21 521P 5P21 621P 6Q21 721P 821P
• Descriptor: GTPASE HRAS, PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C PLC-EPSILON, GUANOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: signaling protein-complex, ras, ubiquitin superfold, oncogene, gtp-binding, nucleotide- binding, signaling protein, disease mutation, lipoprotein, palmitate, prenylation, proto-oncogene
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cell membrane. Isoform 2: Nucleus: P01112
• Total number of polymer chains: 4
• Total formula weight: 66532.44

Authors

Roe, S.M.,Bunney, T.D.,Katan, M.,Pearl, L.H. (deposition date: 2005-10-27, release date: 2006-02-20, Last modification date: 2018-01-24)

• Primary citation: Bunney, T.D.,Harris, R.,Gandarillas, N.L.,Josephs, M.B.,Roe, S.M.,Sorli, S.C.,Paterson, H.F.,Rodrigues-Lima, F.,Esposito, D.,Ponting, C.P.,Gieschik, P.,Pearl, L.H.,Driscoll, P.C.,Katan, M.; Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon; Mol.Cell, 21:495-, 2006; PubMed: 16483931; DOI: 10.1016/J.MOLCEL.2006.01.008

Experimental method

X-RAY DIFFRACTION (1.9 Å)