1K8R

Crystal structure of Ras-Bry2RBD complex

1K8R の概要

• エントリーDOI: 10.2210/pdb1k8r/pdb
• 関連するPDBエントリー: 1C1Y 1HE8 1LFD
• 分子名称: Transforming protein P21/H-RAS-1, Protein kinase byr2, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: signal transduction, cancer, gtpase, ubiquitin fold, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side: P01112
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31847.96

構造登録者

Scheffzek, K.,Gruenewald, P.,Wohlgemuth, S.,Kabsch, W.,Tu, H.,Wigler, M.,Wittinghofer, A.,Herrmann, C. (登録日: 2001-10-25, 公開日: 2002-03-13, 最終更新日: 2023-08-16)

主引用文献

Scheffzek, K.,Grunewald, P.,Wohlgemuth, S.,Kabsch, W.,Tu, H.,Wigler, M.,Wittinghofer, A.,Herrmann, C.
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Structure, 9:1043-1050, 2001

PubMed Abstract: The small GTP binding protein Ras has important roles in cellular growth and differentiation. Mutant Ras is permanently active and contributes to cancer development. In its activated form, Ras interacts with effector proteins, frequently initiating a kinase cascade. In the lower eukaryotic Schizosaccharomyces pombe, Byr2 kinase represents a Ras target that in terms of signal-transduction hierarchy can be considered a homolog of mammalian Raf-kinase. The activation mechanism of protein kinases by Ras is not understood, and there is no detailed structural information about Ras binding domains (RBDs) in nonmammalian organisms.

PubMed: 11709168
DOI: 10.1016/S0969-2126(01)00674-8
主引用文献が同じPDBエントリー

実験手法

X-RAY DIFFRACTION (3 Å)