1HE8

Ras G12V - PI 3-kinase gamma complex

Summary for 1HE8

Related1E8Y 1E8Z
DescriptorPHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM, TRANSFORMING PROTEIN P21/H-RAS-1, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordskinase/hydrolase, complex (phosphoinositide kinase-ras), phosphoinositide 3-kinase gamma - h-ras g12v complex, phosphatidylinositol 3-kinase, pi3k, pi 3-k, pi 3-kinase, second messenger generation, ras effector, h-ras g12v, oncogene protein, gmppnp, gtp, ras-binding domain, heat domain, kinase-hydrolase complex
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight130090.72
Authors
Pacold, M.E.,Suire, S.,Perisic, O.,Lara-Gonzalez, S.,Davis, C.T.,Hawkins, P.T.,Walker, E.H.,Stephens, L.,Eccleston, J.F.,Williams, R.L. (deposition date: 2000-11-20, release date: 2001-01-08, Last modification date: 2019-04-03)
Primary citation
Pacold, M.E.,Suire, S.,Perisic, O.,Lara-Gonzalez, S.,Davis, C.T.,Walker, E.H.,Hawkins, P.T.,Stephens, L.,Eccleston, J.F.,Williams, R.L.
Crystal Structure and Functional Analysis of Ras Binding to its Effector Phosphoinositide 3-Kinase Gamma
Cell(Cambridge,Mass.), 103:931-, 2000
PubMed: 11136978 (PDB entries with the same primary citation)
DOI: 10.1016/S0092-8674(00)00196-3
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26722 2.4% 6.2% 2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25