1HE8
Ras G12V - PI 3-kinase gamma complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM | polymer | 965 | 110627.0 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | HOMO SAPIENS (HUMAN) | PI3-KINASE P110 SUBUNIT GAMMA, PTDINS-3-KINASE P110, PI3K |
| 2 | B (B) | TRANSFORMING PROTEIN P21/H-RAS-1 | polymer | 166 | 18917.3 | 1 | UniProt (P23175) Pfam (PF00071) UniProt (by SIFTS) (P01112) | HOMO SAPIENS (HUMAN) | C-H-RAS, H-RAS |
| 3 | C (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (B) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
A: 1103 - 1108 (PDB: 1HE8)
B: 1 - 166 (UniProt: P23175)
| PDB | External Database | Details |
|---|---|---|
| Lys 223 | Val 222 | engineered mutation |
| Ala 326 | Val 325 | engineered mutation |
B: 1 - 166 (UniProt: P23175)
| PDB | External Database | Details |
|---|---|---|
| Val 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 129544.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 546.5 | |
| All* | Total formula weight | 130090.7 |
