1E8Y

Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine

Summary for 1E8Y

• Entry DOI: 10.2210/pdb1e8y/pdb
• Related: 1E8Z
• Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT (2 entities in total)
• Functional Keywords: phosphoinositide 3-kinase gamma, secondary messenger generation, pi3k, pi 3k
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 110756.16

Authors

Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Wymann, M.P.,Williams, R.L. (deposition date: 2000-10-03, release date: 2000-11-17, Last modification date: 2023-12-13)

• Primary citation: Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Whymann, M.P.,Williams, R.L.; Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine; Mol.Cell, 6:909-, 2000; PubMed: 11090628; DOI: 10.1016/S1097-2765(05)00089-4

Experimental method

X-RAY DIFFRACTION (2 Å)