1OEO

PTP1B with the catalytic cysteine oxidized to sulfonic acid

Summary for 1OEO

Entry DOI	10.2210/pdb1oeo/pdb
Related	1A5Y 1AAX 1BZC 1BZH 1BZJ 1C83 1C84 1C85 1C86 1C87 1C88 1ECV 1EEN 1EEO 1G1F 1G1G 1G1H 1G7F 1G7G 1GFY 1I57 1JF7 1KAK 1KAV 1L8G 1LQF 1N6W 1NL9 1NNY 1NO6 1NWL 1OEM 1OES 1OET 1OEU 1OEV 1PTT 1PTU 1PTV 1PTY 2HNP 2HNQ
Descriptor	PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (2 entities in total)
Functional Keywords	hydrolase, phosphorylation, cysteine sulfonic acid
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	37413.64
Authors	Salmeen, A.,Andersen, J.N.,Myers, M.P.,Meng, T.C.,Hinks, J.A.,Tonks, N.K.,Barford, D. (deposition date: 2003-03-28, release date: 2003-06-12, Last modification date: 2023-12-13)
Primary citation	Salmeen, A.,Andersen, J.N.,Myers, M.P.,Meng, T.C.,Hinks, J.A.,Tonks, N.K.,Barford, D. Redox Regulation of Protein Tyrosine Phosphatase Involves a Sulfenyl-Amide Intermediate Nature, 423:769-, 2003 Cited by PubMed: 12802338 DOI: 10.1038/NATURE01680 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation