1H1Q

Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094

1H1Q の概要

関連するPDBエントリー1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1R 1H1S 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1QMZ
分子名称CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE, ... (4 entities in total)
機能のキーワードkinase, transferase, serine/threonine-protein kinase, atp-binding, cell cycle, cell division, mitosis, phosphorylation
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Nucleus P20248
ポリマー鎖数4
分子量合計128831.23
構造登録者
Davies, T.G.,Noble, M.E.M.,Endicott, J.A.,Johnson, L.N. (登録日: 2002-07-21, 公開日: 2002-09-19, 最終更新日: 2011-07-13)
主引用文献
Davies, T.G.,Bentley, J.,Arris, C.E.,Boyle, F.T.,Curtin, N.J.,Endicott, J.A.,Gibson, A.E.,Golding, B.T.,Griffin, R.J.,Hardcastle, I.R.,Jewsbury, P.,Johnson, L.N.,Mesguiche, V.,Newell, D.R.,Noble, M.E.M.,Tucker, J.A.,Wang, L.,Whitfield, H.J.
Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor
Nat.Struct.Biol., 9:745-, 2002
PubMed: 12244298 (主引用文献が同じPDBエントリー)
DOI: 10.1038/NSB842
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.5 Å)
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.296292.6%13.7%10.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード