1GZ8
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 2-Amino-6-(3'-methyl-2'-oxo)butoxypurine
Summary for 1GZ8
Entry DOI | 10.2210/pdb1gz8/pdb |
Related | 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1QMZ |
Descriptor | CELL DIVISION PROTEIN KINASE 2, 1-[(2-AMINO-6,9-DIHYDRO-1H-PURIN-6-YL)OXY]-3-METHYL-2-BUTANOL (3 entities in total) |
Functional Keywords | kinase, protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase, serine/threonine-protein kinase, atp-binding, 3d-structure. |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 34269.77 |
Authors | Davies, T.,Endicott, J.,Johnson, L.,Noble, M.,Tucker, J. (deposition date: 2002-05-17, release date: 2003-06-12, Last modification date: 2023-12-13) |
Primary citation | Gibson, A.E.,Arris, C.E.,Bentley, J.,Boyle, F.T.,Curtin, N.J.,Davies, T.G.,Endicott, J.A.,Golding, B.T.,Grant, S.,Griffin, R.J.,Jewsbury, P.,Johnson, L.N.,Mesguiche, V.,Newell, D.R.,Noble, M.E.,Tucker, J.A.,Whitfield, H.J. Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O(6)-Substituted Guanine Derivatives J.Med.Chem., 45:3381-, 2002 Cited by PubMed: 12139449DOI: 10.1021/JM020056Z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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