1FKO
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Summary for 1FKO
Entry DOI | 10.2210/pdb1fko/pdb |
Related | 1c0t 1c0u 1c1b 1c1c 1dtq 1dtt 1ep4 1fk9 1fkp 1klm 1rev 1rt1 1rt2 1rt3 1rt4 1rt5 1rt6 1rt7 1rth 1rti 1rtj 1rtv 1vru |
Descriptor | HIV-1 RT, A-CHAIN, HIV-1 RT, B-CHAIN, (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE (3 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, dmp-266, efavirenz, drug resistance mutation, drug design, transferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 114468.39 |
Authors | Ren, J.,Milton, J.,Weaver, K.L.,Short, S.A.,Stuart, D.I.,Stammers, D.K. (deposition date: 2000-08-10, release date: 2000-11-03, Last modification date: 2018-03-14) |
Primary citation | Ren, J.,Milton, J.,Weaver, K.L.,Short, S.A.,Stuart, D.I.,Stammers, D.K. Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase. Structure Fold.Des., 8:1089-1094, 2000 Cited by PubMed: 11080630DOI: 10.1016/S0969-2126(00)00513-X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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