1EB2
Trypsin inhibitor complex (BPO)
Summary for 1EB2
| Entry DOI | 10.2210/pdb1eb2/pdb |
| Related | 1AQ7 1AUJ 1AZ8 1BJU 1BJV 1BTP 1BTW 1BTX 1BTY 1BTZ 1C1N 1C1O 1C1P 1C1Q 1C1R 1C1S 1C1T 1C2D 1C2E 1C2F 1C2G 1C2H 1C2I 1C2J 1C2K 1C2L 1C2M 1C5P 1C5Q 1C5R 1C5S 1C5T 1C5U 1C5V 1C9T 1CE5 1CU7 1CU8 1CU9 1D6R 1EJM 1EZX 1F0T 1F0U 1F2S 1G3B 1G3C 1G3D 1G3E 1G9I 1GBT 1HJ9 1JRS 1JRT 1MAX 1MAY 1MTS 1MTU 1MTV 1MTW 1NTP 1PPC 1PPE 1PPH 1QA0 1QB1 1QB6 1QB9 1QBN 1QBO 1QCP 1QL7 1QL8 1SBW 1SFI 1SMF 1TAB 1TAW 1TGB 1TGC 1TGN 1TGS 1TGT 1TIO 1TLD 1TNG 1TNH 1TNI 1TNJ 1TNK 1TNL 1TPA 1TPO 1TPP 1TPS 1TYN 1XUF 1XUG 1XUH 1XUI 1XUJ 1XUK 1YYY 1ZZZ 2BTC 2BZA 2PTC 2PTN 2TGA 2TGD 2TGP 2TGT 2TIO 2TLD 2TPI 3BTD 3BTE 3BTF 3BTG 3BTH 3BTK 3BTM 3BTQ 3BTT 3BTW 3PTB 3PTN 3TGJ 3TPI 4TPI 5PTP |
| Descriptor | TRYPSIN, SULFATE ION, CALCIUM ION, ... (5 entities in total) |
| Functional Keywords | serine protease, inhibitor, hydrolase |
| Biological source | BOS TAURUS (BOVINE) |
| Cellular location | Secreted, extracellular space: P00760 |
| Total number of polymer chains | 1 |
| Total formula weight | 23928.97 |
| Authors | Wilkinson, K.W.,Young, S.C.,Liebeschuetz, J.W.,Brady, R.L. (deposition date: 2001-07-18, release date: 2002-02-11, Last modification date: 2023-12-13) |
| Primary citation | Liebeschuetz, J.W.,Jones, S.D.,Morgan, P.J.,Murray, C.W.,Rimmer, A.D.,Roscoe, J.M.E.,Waszkowycz, B.,Welsh, P.M.,Wylie, W.A.,Young, S.C.,Martin, H.,Mahler, J.,Brady, R.L.,Wilkinson, K.W. Pro_Select: Combining Structure-Based Drug Design and Array-Based Chemistry for Rapid Lead Discovery. 2. The Development of a Series of Highly Potent and Selective Factor Xa Inhibitors J.Med.Chem., 45:1221-, 2002 Cited by PubMed Abstract: In silico screening of combinatorial libraries prior to synthesis promises to be a valuable aid to lead discovery. PRO_SELECT, a tool for the virtual screening of libraries for fit to a protein active site, has been used to find novel leads against the serine protease factor Xa. A small seed template was built upon using three iterations of library design, virtual screening, synthesis, and biological testing. Highly potent molecules with selectivity for factor Xa over other serine proteases were rapidly obtained. PubMed: 11881991DOI: 10.1021/JM010944E PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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