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4Z80
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BU of 4z80 by Molmil
Crystal structure of Toxoplasma gondii AMA4 DI-DII-EGF1 in complex with a 33 aa TgRON2L1 peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytoadherence-linked asexual protein, EGF family domain-containing protein, ...
Authors:Parker, M.L, Boulanger, M.J.
Deposit date:2015-04-08
Release date:2015-12-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair.
Proc.Natl.Acad.Sci.USA, 113, 2016
4Z81
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BU of 4z81 by Molmil
Crystal structure of AMA4 DI-DII-EGF1 from Toxoplasma gondii
Descriptor: EGF family domain-containing protein, GLYCEROL
Authors:Parker, M.L, Boulanger, M.J.
Deposit date:2015-04-08
Release date:2015-12-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair.
Proc.Natl.Acad.Sci.USA, 113, 2016
6BXJ
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BU of 6bxj by Molmil
Structure of a single-chain beta3 integrin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera protein of Integrin beta-3 and Integrin alpha-L, MAGNESIUM ION
Authors:Thinn, A.M.M, Wang, Z, Zhou, D, Zhao, Y, Curtis, B.R, Zhu, J.
Deposit date:2017-12-18
Release date:2018-10-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Autonomous conformational regulation of beta3integrin and the conformation-dependent property of HPA-1a alloantibodies.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3G5C
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BU of 3g5c by Molmil
Structural and biochemical studies on the ectodomain of human ADAM22
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADAM 22, CALCIUM ION
Authors:Liu, H, Shim, A, Chen, X, He, X.
Deposit date:2009-02-04
Release date:2009-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural and biochemical studies on the ectodomain of human ADAM22
J.Biol.Chem., 2009
7PGN
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BU of 7pgn by Molmil
HHP-C in complex with glycosaminoglycan mimic SOS
Descriptor: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CALCIUM ION, GLYCEROL, ...
Authors:Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C.
Deposit date:2021-08-14
Release date:2021-12-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021
3FCS
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BU of 3fcs by Molmil
Structure of complete ectodomain of integrin aIIBb3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Zhu, J, Luo, B.-H, Xiao, T, Zhang, C, Nishida, N, Springer, T.A.
Deposit date:2008-11-22
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
2WG3
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BU of 2wg3 by Molmil
Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DESERT HEDGEHOG PROTEIN N-PRODUCT, ...
Authors:Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C.
Deposit date:2009-04-15
Release date:2009-06-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Nat.Struct.Mol.Biol., 16, 2009
5Y2Z
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BU of 5y2z by Molmil
Crystal structure of human LGI1 EPTP-ADAM22 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yamagata, A, Fukai, S.
Deposit date:2017-07-27
Release date:2018-05-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Nat Commun, 9, 2018
7PGM
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BU of 7pgm by Molmil
HHIP-C in complex with heparin
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hedgehog-interacting protein
Authors:Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C.
Deposit date:2021-08-14
Release date:2021-12-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Nat Commun, 12, 2021
8ZJF
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BU of 8zjf by Molmil
Cryo-EM structure of human integrin alpha-E beta-7
Descriptor: CALCIUM ION, Integrin alpha-E, Integrin beta-7, ...
Authors:Akasaka, H, Nureki, O, Kise, Y.
Deposit date:2024-05-14
Release date:2024-06-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structure of I domain-containing integrin alpha E beta 7.
Biochem.Biophys.Res.Commun., 721, 2024
2WFT
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BU of 2wft by Molmil
Crystal structure of the human HIP ectodomain
Descriptor: CHLORIDE ION, HEDGEHOG-INTERACTING PROTEIN, SODIUM ION
Authors:Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C.
Deposit date:2009-04-15
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Nat.Struct.Mol.Biol., 16, 2009
6V4P
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BU of 6v4p by Molmil
Structure of the integrin AlphaIIbBeta3-Abciximab complex
Descriptor: Abciximab, heavy chain, light chain, ...
Authors:Nesic, D, Zhang, Y, Spasic, A, Li, J, Provasi, D, Filizola, M, Walz, T, Coller, B.S.
Deposit date:2019-11-28
Release date:2020-02-05
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-Electron Microscopy Structure of the alpha IIb beta 3-Abciximab Complex.
Arterioscler Thromb Vasc Biol., 40, 2020
4UM8
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BU of 4um8 by Molmil
Crystal structure of alpha V beta 6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ...
Authors:Dong, X, Springer, T.A.
Deposit date:2014-05-15
Release date:2014-11-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.852 Å)
Cite:Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta
Nat.Struct.Mol.Biol., 21, 2014
4G1M
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BU of 4g1m by Molmil
Re-refinement of alpha V beta 3 structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Springer, T.A, Mi, L, Zhu, J.
Deposit date:2012-07-10
Release date:2012-12-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Alpha V Beta 3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
3IJE
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BU of 3ije by Molmil
Crystal structure of the complete integrin alhaVbeta3 ectodomain plus an Alpha/beta transmembrane fragment
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Xiong, J.-P, Mahalingham, B, Rui, X, Hyman, B.T, Goodman, S.L, Arnaout, M.A.
Deposit date:2009-08-04
Release date:2009-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
J.Cell Biol., 186, 2009
3HO3
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BU of 3ho3 by Molmil
Crystal structure of Hedgehog-interacting protein (HHIP)
Descriptor: Hedgehog-interacting protein
Authors:Bosanac, I, Hymowitz, S.G.
Deposit date:2009-06-01
Release date:2009-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
8HQ2
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BU of 8hq2 by Molmil
Crystal structure of human ADAM22 in complex with human LGI1 mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 22, ...
Authors:Liu, H, Lin, Z, Xu, F.
Deposit date:2022-12-13
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Crystal structure of human ADAM22 in complex with human LGI1 mutant
To Be Published
8GCD
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BU of 8gcd by Molmil
Full length Integrin AlphaIIbBeta3 in inactive state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Huo, T, Wu, H, Wang, Z.
Deposit date:2023-03-01
Release date:2024-03-06
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 32, 2024
4G1E
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BU of 4g1e by Molmil
Crystal structure of integrin alpha V beta 3 with coil-coiled tag.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Dong, X, Mi, L, Zhu, J, Wang, W, Luo, B, Springer, T.A.
Deposit date:2012-07-10
Release date:2012-12-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:AlphaV Beta3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
6MK0
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BU of 6mk0 by Molmil
Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161
Descriptor: (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:van Agthoven, J, Arnaout, M.A.
Deposit date:2018-09-24
Release date:2019-09-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
Acs Pharmacol Transl Sci, 2, 2019
3HO5
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BU of 3ho5 by Molmil
Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
Descriptor: CALCIUM ION, Hedgehog-interacting protein, Sonic hedgehog protein, ...
Authors:Hymowitz, S.G, Bosanac, I.
Deposit date:2009-06-01
Release date:2009-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
7NWL
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BU of 7nwl by Molmil
Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-5, ...
Authors:Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N.
Deposit date:2021-03-17
Release date:2021-06-02
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.
Sci Adv, 7, 2021
6NAJ
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BU of 6naj by Molmil
Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
Authors:van Agthoven, J, Arnaout, M.A.
Deposit date:2018-12-05
Release date:2019-12-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-guided design of pure orthosteric inhibitors of alpha IIb beta 3 that prevent thrombosis but preserve hemostasis.
Nat Commun, 11, 2020
4MMZ
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BU of 4mmz by Molmil
Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ...
Authors:van Agthoven, J, Xiong, J, Arnaout, M.A.
Deposit date:2013-09-09
Release date:2014-03-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
3HO4
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BU of 3ho4 by Molmil
Crystal structure of Hedgehog-interacting protein (HHIP)
Descriptor: Hedgehog-interacting protein
Authors:Hymowitz, S.G, Bosanac, I.
Deposit date:2009-06-01
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009

 

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