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8PU0
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BU of 8pu0 by Molmil
Cryo-EM structure of human Elp123 in complex with tRNA, desulpho-CoA, 5'-deoxyadenosine and methionine
Descriptor: 5'-DEOXYADENOSINE, DESULFO-COENZYME A, Elongator complex protein 1, ...
Authors:Abbassi, N, Jaciuk, M, Lin, T.-Y, Glatt, S.
Deposit date:2023-07-16
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Cryo-EM structures of the human Elongator complex at work.
Nat Commun, 15, 2024
8PTZ
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BU of 8ptz by Molmil
Cryo-EM structure of human Elp123 in complex with tRNA, S-ethyl-CoA, 5'-deoxyadenosine and methionine
Descriptor: 5'-DEOXYADENOSINE, Elongator complex protein 1, Elongator complex protein 2, ...
Authors:Abbassi, N, Jaciuk, M, Lin, T.-Y, Glatt, S.
Deposit date:2023-07-16
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structures of the human Elongator complex at work.
Nat Commun, 15, 2024
8PTY
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BU of 8pty by Molmil
Cryo-EM structure of human Elp123 in complex with 5'-deoxyadenosine and methionine
Descriptor: 5'-DEOXYADENOSINE, Elongator complex protein 1, Elongator complex protein 2, ...
Authors:Abbassi, N, Jaciuk, M, Lin, T.-Y, Glatt, S.
Deposit date:2023-07-16
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Cryo-EM structures of the human Elongator complex at work.
Nat Commun, 15, 2024
8PTX
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Cryo-EM structure of human Elp123 in complex with tRNA, acetyl-CoA, 5'-deoxyadenosine and methionine
Descriptor: 5'-DEOXYADENOSINE, ACETYL COENZYME *A, Elongator complex protein 1, ...
Authors:Abbassi, N, Jaciuk, M, Lin, T.-Y, Glatt, S.
Deposit date:2023-07-16
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Cryo-EM structures of the human Elongator complex at work.
Nat Commun, 15, 2024
8VPO
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BU of 8vpo by Molmil
X-Ray Crystal Structure of TigE from Paramaledivibacter caminithermalis
Descriptor: GLYCEROL, IRON/SULFUR CLUSTER, Radical SAM core domain-containing protein
Authors:Grove, T.L, Lachowicz, J.C, Zizola, C.
Deposit date:2024-01-16
Release date:2024-02-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases.
Acs Chem.Biol., 19, 2024
8VCW
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X-Ray Crystal Structure of the biotin synthase from B. obeum
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, Biotin synthase, ...
Authors:Lachowicz, J.C, Grove, T.L.
Deposit date:2023-12-14
Release date:2024-01-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe-5S Cluster for Sulfur Insertion.
J.Am.Chem.Soc., 146, 2024
8AI6
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BU of 8ai6 by Molmil
Crystal structure of radical SAM epimerase EpeE D210A mutant from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and persulfurated cysteine bound
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, ...
Authors:Polsinelli, I, Legrand, P, Fyfe, C.D, Benjdia, A, Berteau, O.
Deposit date:2022-07-25
Release date:2024-01-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.
Nat.Chem.Biol., 20, 2024
8AI1
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BU of 8ai1 by Molmil
Crystal structure of radical SAM epimerase EpeE from Bacillus subtilis with [4Fe-4S] clusters and S-adenosyl-L-homocysteine bound.
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, ...
Authors:Kubiak, X, Polsinelli, I, Chavas, L.M.G, Legrand, P, Fyfe, C.D, Benjdia, A, Berteau, O.
Deposit date:2022-07-25
Release date:2024-01-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.
Nat.Chem.Biol., 20, 2024
8AI4
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BU of 8ai4 by Molmil
Crystal structure of radical SAM epimerase EpeE C223A mutant from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and RiPP peptide 5 bound
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Polsinelli, I, Fyfe, C.D, Legrand, P, Kubiak, X, Chavas, L.M.G, Berteau, O, Benjdia, A.
Deposit date:2022-07-25
Release date:2024-01-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.
Nat.Chem.Biol., 20, 2024
8AI3
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BU of 8ai3 by Molmil
Crystal structure of radical SAM epimerase EpeE C223A mutant from Bacillus subtilis with [4Fe-4S] clusters and S-adenosyl-L-methionine bound
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, IRON/SULFUR CLUSTER, ...
Authors:Kubiak, X, Chavas, L.M.G, Legrand, P, Polsinelli, I, Fyfe, C.D, Benjdia, A, Berteau, O.
Deposit date:2022-07-25
Release date:2024-01-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.
Nat.Chem.Biol., 20, 2024
8AI2
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BU of 8ai2 by Molmil
Crystal structure of radical SAM epimerase EpeE from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and RiPP peptide 5 bound
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, ...
Authors:Polsinelli, I, Fyfe, C.D, Legrand, P, Kubiak, X, Chavas, L.M.G, Berteau, O, Benjdia, A.
Deposit date:2022-07-25
Release date:2024-01-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.
Nat.Chem.Biol., 20, 2024
8AI5
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BU of 8ai5 by Molmil
Crystal structure of radical SAM epimerase EpeE C223A mutant from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and RiPP peptide 6 bound
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, ...
Authors:Polsinelli, I, Fyfe, C.D, Legrand, P, Kubiak, X, Chavas, L.M.G, Berteau, O, Benjdia, A.
Deposit date:2022-07-25
Release date:2024-01-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.
Nat.Chem.Biol., 20, 2024
8QMN
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BU of 8qmn by Molmil
[FeFe]-hydrogenase maturase HydE from T. maritima - dialysis experiment - empty structure
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CHLORIDE ION, IRON/SULFUR CLUSTER, ...
Authors:Omeiri, J, Martin, L, Usclat, A, Cherrier, M.V, Nicolet, Y.
Deposit date:2023-09-23
Release date:2023-11-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Maturation of the [FeFe]-Hydrogenase: Direct Transfer of the ( kappa 3 -cysteinate)Fe II (CN)(CO) 2 Complex B from HydG to HydE.
Angew.Chem.Int.Ed.Engl., 62, 2023
8QMM
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BU of 8qmm by Molmil
M291I variant of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CHLORIDE ION, IRON/SULFUR CLUSTER, ...
Authors:Omeiri, J, Martin, L, Usclat, A, Cherrier, M.V, Nicolet, Y.
Deposit date:2023-09-23
Release date:2023-11-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Maturation of the [FeFe]-Hydrogenase: Direct Transfer of the ( kappa 3 -cysteinate)Fe II (CN)(CO) 2 Complex B from HydG to HydE.
Angew.Chem.Int.Ed.Engl., 62, 2023
8QML
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BU of 8qml by Molmil
(2R,4R)-MeTDA bound HydE structure (control experiment)
Descriptor: (2R,4R)-2-methyl-1,3-thiazolidine-2,4-dicarboxylic acid, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CHLORIDE ION, ...
Authors:Omeiri, J, Martin, L, Usclat, A, Cherrier, M.V, Nicolet, Y.
Deposit date:2023-09-22
Release date:2023-11-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Maturation of the [FeFe]-Hydrogenase: Direct Transfer of the ( kappa 3 -cysteinate)Fe II (CN)(CO) 2 Complex B from HydG to HydE.
Angew.Chem.Int.Ed.Engl., 62, 2023
8QMK
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BU of 8qmk by Molmil
Enzymatically-produced complex-B bound TmHydE structure
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CARBON MONOXIDE, CHLORIDE ION, ...
Authors:Omeiri, J, Martin, L, Usclat, A, Cherrier, M.V, Nicolet, Y.
Deposit date:2023-09-22
Release date:2023-11-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Maturation of the [FeFe]-Hydrogenase: Direct Transfer of the ( kappa 3 -cysteinate)Fe II (CN)(CO) 2 Complex B from HydG to HydE.
Angew.Chem.Int.Ed.Engl., 62, 2023
8FO0
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BU of 8fo0 by Molmil
The structure of a crystallizable variant of E. coli pyruvate formate-lyase activating enzyme bound to a partially cleaved SAM molecule
Descriptor: IRON/SULFUR CLUSTER, POTASSIUM ION, Pyruvate formate-lyase 1-activating enzyme, ...
Authors:Moody, J.D, Saxton, A.J, Galambas, A, Lawrence, C.M, Broderick, J.B.
Deposit date:2022-12-29
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage.
J.Biol.Chem., 299, 2023
8FOL
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BU of 8fol by Molmil
The structure of a crystallizable variant of E. coli pyruvate formate-lyase activating enzyme bound to SAM, alternate crystal form
Descriptor: CHLORIDE ION, IRON/SULFUR CLUSTER, POTASSIUM ION, ...
Authors:Moody, J.D, Saxton, A.J, Galambas, A, Lawrence, C.M, Broderick, J.B.
Deposit date:2022-12-31
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage.
J.Biol.Chem., 299, 2023
8FSI
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BU of 8fsi by Molmil
The structure of a crystallizable variant of E. coli pyruvate formate-lyase activating enzyme bound to SAM
Descriptor: CHLORIDE ION, IRON/SULFUR CLUSTER, POTASSIUM ION, ...
Authors:Moody, J.D, Galambas, A, Lawrence, C.M, Broderick, J.B.
Deposit date:2023-01-10
Release date:2023-05-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage.
J.Biol.Chem., 299, 2023
7WZX
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BU of 7wzx by Molmil
The structure of a Twitch Radical SAM Dehydrogenase SpeY
Descriptor: (2~{S},4~{S},6~{R})-2-[(2~{S},3~{R},5~{S},6~{R})-3,5-bis(methylamino)-2,4,6-tris(oxidanyl)cyclohexyl]oxy-6-methyl-4-oxidanyl-oxan-3-one, 4Fe-4S cluster-binding domain-containing protein, GLYCEROL, ...
Authors:Hou, X.L, Zhou, J.H.
Deposit date:2022-02-19
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.980013 Å)
Cite:Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.
J.Am.Chem.Soc., 144, 2022
7X0B
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BU of 7x0b by Molmil
The structure of a Twitch Radical SAM Dehydrogenase SpeY
Descriptor: 4Fe-4S cluster-binding domain-containing protein, CHLORIDE ION, GLYCEROL, ...
Authors:Hou, X.L, Zhou, J.H.
Deposit date:2022-02-21
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.02027535 Å)
Cite:Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.
J.Am.Chem.Soc., 144, 2022
7WZV
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BU of 7wzv by Molmil
The structure of a Twitch Radical SAM Dehydrogenase SpeY
Descriptor: (1~{S},2~{R},4~{S},5~{R})-2,4-bis(methylamino)-6-[(2~{S},3~{R},4~{S},6~{R})-6-methyl-3,4-bis(oxidanyl)oxan-2-yl]oxy-cyclohexane-1,3,5-triol, 1,2-ETHANEDIOL, 4Fe-4S cluster-binding domain-containing protein, ...
Authors:Zhou, J.H, Hou, X.L.
Deposit date:2022-02-19
Release date:2022-12-28
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.899313 Å)
Cite:Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.
J.Am.Chem.Soc., 144, 2022
8ASW
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BU of 8asw by Molmil
Cryo-EM structure of yeast Elp123 in complex with alanine tRNA
Descriptor: 5'-DEOXYADENOSINE, Alanine tRNA, Elongator complex protein 1, ...
Authors:Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S.
Deposit date:2022-08-21
Release date:2022-12-07
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Cryo-EM structure of the fully assembled Elongator complex.
Nucleic Acids Res., 51, 2023
8ASV
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BU of 8asv by Molmil
Cryo-EM structure of yeast Elongator complex
Descriptor: Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ...
Authors:Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S.
Deposit date:2022-08-21
Release date:2022-12-07
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (4.35 Å)
Cite:Cryo-EM structure of the fully assembled Elongator complex.
Nucleic Acids Res., 51, 2023
8AVG
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BU of 8avg by Molmil
Cryo-EM structure of mouse Elp123 with bound SAM
Descriptor: Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ...
Authors:Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S.
Deposit date:2022-08-26
Release date:2022-12-07
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (4.01 Å)
Cite:Cryo-EM structure of the fully assembled Elongator complex.
Nucleic Acids Res., 51, 2023

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PDB entries from 2024-09-18

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