8AI2
Crystal structure of radical SAM epimerase EpeE from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and RiPP peptide 5 bound
Summary for 8AI2
Entry DOI | 10.2210/pdb8ai2/pdb |
Descriptor | Putative peptide biosynthesis protein YydG, Putative exported peptide YydF, IRON/SULFUR CLUSTER, ... (7 entities in total) |
Functional Keywords | radical sam, metalloenzyme, iron-sulfur, ripp, metal binding protein |
Biological source | Bacillus subtilis More |
Total number of polymer chains | 4 |
Total formula weight | 86777.70 |
Authors | Polsinelli, I.,Fyfe, C.D.,Legrand, P.,Kubiak, X.,Chavas, L.M.G.,Berteau, O.,Benjdia, A. (deposition date: 2022-07-25, release date: 2024-01-10, Last modification date: 2024-03-13) |
Primary citation | Kubiak, X.,Polsinelli, I.,Chavas, L.M.G.,Fyfe, C.D.,Guillot, A.,Fradale, L.,Brewee, C.,Grimaldi, S.,Gerbaud, G.,Thureau, A.,Legrand, P.,Berteau, O.,Benjdia, A. Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme. Nat.Chem.Biol., 20:382-391, 2024 Cited by PubMed: 38158457DOI: 10.1038/s41589-023-01493-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.393 Å) |
Structure validation
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