8VCW

X-Ray Crystal Structure of the biotin synthase from B. obeum

Summary for 8VCW

Entry DOI	10.2210/pdb8vcw/pdb
Descriptor	Biotin synthase, S-ADENOSYLMETHIONINE, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (9 entities in total)
Functional Keywords	biotin, iron sulfur cluster, desthiobiotin, radical sam, transferase
Biological source	Blautia obeum
Total number of polymer chains	1
Total formula weight	37980.99
Authors	Lachowicz, J.C.,Grove, T.L. (deposition date: 2023-12-14, release date: 2024-01-24, Last modification date: 2024-02-07)
Primary citation	Lachowicz, J.C.,Lennox-Hvenekilde, D.,Myling-Petersen, N.,Salomonsen, B.,Verkleij, G.,Acevedo-Rocha, C.G.,Caddell, B.,Gronenberg, L.S.,Almo, S.C.,Sommer, M.O.A.,Genee, H.J.,Grove, T.L. Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe-5S Cluster for Sulfur Insertion. J.Am.Chem.Soc., 146:1860-1873, 2024 Cited by PubMed: 38215281 DOI: 10.1021/jacs.3c05481 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation