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9IJP
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BU of 9ijp by Molmil
Polyphosphate bound alpha-synuclein fibril
Descriptor: Alpha-synuclein, Tetraphosphate
Authors:Tao, Y.Q, Liu, C, Li, D.
Deposit date:2024-06-25
Release date:2024-07-17
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Polyphosphate bound alpha-synuclein fibril
To Be Published
9FYP
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BU of 9fyp by Molmil
Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.
Descriptor: Alpha-synuclein, CHLORIDE ION
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2024-07-03
Release date:2024-07-17
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.23 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Elife, 12, 2024
9EUU
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BU of 9euu by Molmil
Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo
Descriptor: Alpha-synuclein
Authors:Burger, D, Kashyrina, M, Lewis, A, De Nuccio, F, Mohammed, I, de La Seigliere, H, van den Heuvel, L, Feuillie, C, Verchere, J, Berbon, M, Arotcarena, M, Retailleau, A, Bezard, E, Laferriere, F, Loquet, A, Bousset, L, Baron, T, Lofrumento, D.D, De Giorgi, F, Stahlberg, H, Ichas, F.
Deposit date:2024-03-28
Release date:2024-06-05
Method:ELECTRON MICROSCOPY (1.93 Å)
Cite:Multiple System Atrophy: Insights from aSyn Fibril Structure
To Be Published
9CX6
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BU of 9cx6 by Molmil
Cryo-EM filament structure in FTLD-synuclein
Descriptor: Alpha-synuclein
Authors:Yang, Y, Scheres, H.W.S, Goedert, M.
Deposit date:2024-07-30
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM filament structure in FTLD-synuclein from typical multiple system atrophy brain
To Be Published
9CK3
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BU of 9ck3 by Molmil
Cryo-EM structure of in-vitro alpha-synuclein fibril
Descriptor: Alpha-synuclein
Authors:Sanchez, J.C, Borcik, C.G, Tonelli, M, Sibert, B, Rienstra, C.M, Wright, E.R.
Deposit date:2024-07-08
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (2.04 Å)
Cite:Multimodal High-Resolution Structure Determination Of Alpha-Synuclein Fibrils
To Be Published
8ZWK
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BU of 8zwk by Molmil
Polyadenylic acid bound alpha-synuclein fibril Polymorph 2
Descriptor: Alpha-synuclein, RNA (5'-R(P*AP*AP*A)-3')
Authors:Tao, Y.Q, Liu, C, Li, D.
Deposit date:2024-06-13
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Polyadenylic acid bound alpha-synuclein fibril Polymorph 2
To Be Published
8ZWJ
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BU of 8zwj by Molmil
Polyadenylic acid bound alpha-synuclein fibril Polymorph 1
Descriptor: Alpha-synuclein, RNA (5'-R(P*AP*AP*A)-3')
Authors:Tao, Y.Q, Liu, C, Li, D.
Deposit date:2024-06-13
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Polyadenylic acid bound alpha-synuclein fibril Polymorph 1
To Be Published
8ZWI
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BU of 8zwi by Molmil
Chondroitin sulfate bound alpha-synuclein fibril
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Liu, C, Li, D.
Deposit date:2024-06-13
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Chondroitin sulfate bound alpha-synuclein fibril
To Be Published
8ZWH
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BU of 8zwh by Molmil
Heparin bound E46K alpha-synuclein fibril
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Liu, C, Li, D.
Deposit date:2024-06-13
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Heparin bound E46K alpha-synuclein fibril
To Be Published
8RRR
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BU of 8rrr by Molmil
Alpha-synuclein amyloid fibril
Descriptor: Alpha-synuclein
Authors:Saibil, H.R, Monistrol, J.
Deposit date:2024-01-23
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
Biorxiv, 2024
8RQM
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BU of 8rqm by Molmil
Alpha-synuclein amyloid fibrils
Descriptor: Alpha-synuclein
Authors:Saibil, H.R, Monistrol, J.
Deposit date:2024-01-18
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
Biorxiv, 2024
8RI9
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BU of 8ri9 by Molmil
Late alpha-Synuclein fibril structure from liquid-liquid phase separations.
Descriptor: Alpha-synuclein
Authors:De Simone, A, Barritt, J.D, Chen, S, Cascella, R, Cecchi, C, Bigi, A, Jarvis, J.A, Chiti, F, Dobson, C.M, Fusco, G.
Deposit date:2023-12-18
Release date:2024-03-06
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure-Toxicity Relationship in Intermediate Fibrils from alpha-Synuclein Condensates.
J.Am.Chem.Soc., 146, 2024
8QPZ
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BU of 8qpz by Molmil
CryoEM structure of recombinant DeltaN7 alpha-synuclein in PBS
Descriptor: Alpha-synuclein
Authors:Thacker, D, Wilkinson, M, Dewison, K.M, Ranson, N.A, Brockwell, D.J, Radford, S.E.
Deposit date:2023-10-03
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Residues 2 to 7 of alpha-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways.
Proc.Natl.Acad.Sci.USA, 121, 2024
8PK4
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BU of 8pk4 by Molmil
Cryo EM structure of the type 5A polymorph of alpha-synuclein.
Descriptor: Alpha-synuclein
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2023-06-24
Release date:2024-05-29
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Elife, 12, 2024
8PK2
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BU of 8pk2 by Molmil
Cryo EM structure of the type 1m polymorph of alpha-synuclein
Descriptor: Alpha-synuclein
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2023-06-24
Release date:2024-05-29
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Elife, 12, 2024
8PJO
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BU of 8pjo by Molmil
Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH.
Descriptor: Alpha-synuclein, CHLORIDE ION
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2023-06-23
Release date:2024-05-29
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.31 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Elife, 12, 2024
8PIX
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BU of 8pix by Molmil
Cryo EM structure of the type 3C polymorph of alpha-synuclein at low pH.
Descriptor: Alpha-synuclein
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2023-06-22
Release date:2024-05-29
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.
Elife, 12, 2024
8OQI
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BU of 8oqi by Molmil
Cryo-EM structure of the wild-type alpha-synuclein fibril.
Descriptor: Alpha-synuclein
Authors:Pesch, V, Reithofer, S, Ma, L, Flores-Fernandez, J.M, Oezduezenciler, P, Busch, Y, Lien, Y, Rudtke, O, Frieg, B, Schroeder, G.F, Wille, H, Tamgueney, G.
Deposit date:2023-04-12
Release date:2024-03-13
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson's disease.
Brain, 147, 2024
8JEY
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BU of 8jey by Molmil
Cryo-EM structure of alpha-synuclein pS87 fibril
Descriptor: Alpha-synuclein
Authors:Xia, W.C, Sun, Y.P, Liu, C.
Deposit date:2023-05-16
Release date:2024-04-17
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures.
Nat Commun, 15, 2024
8JEX
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BU of 8jex by Molmil
Cryo-EM structure of alpha-synuclein gS87 fibril
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein, unverified amino acid chain
Authors:Xia, W.C, Sun, Y.P, Liu, C.
Deposit date:2023-05-16
Release date:2024-04-17
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures.
Nat Commun, 15, 2024
8HZS
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BU of 8hzs by Molmil
Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3)
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
Deposit date:2023-01-09
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3)
To Be Published
8HZC
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BU of 8hzc by Molmil
Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2)
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
Deposit date:2023-01-08
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2)
To Be Published
8HZB
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BU of 8hzb by Molmil
Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1)
Descriptor: Alpha-synuclein
Authors:Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
Deposit date:2023-01-08
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1)
To Be Published
8H05
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BU of 8h05 by Molmil
Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-09-28
Release date:2022-11-30
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023
8H04
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BU of 8h04 by Molmil
Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient
Descriptor: Alpha-synuclein
Authors:Fan, Y, Sun, Y.P, Wang, J, Liu, C.
Deposit date:2022-09-28
Release date:2022-11-30
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease.
Structure, 31, 2023

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PDB entries from 2024-09-18

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