8QPZ
CryoEM structure of recombinant DeltaN7 alpha-synuclein in PBS
Summary for 8QPZ
Entry DOI | 10.2210/pdb8qpz/pdb |
EMDB information | 18570 |
Descriptor | Alpha-synuclein (1 entity in total) |
Functional Keywords | synuclein, parkinson's disease, neurodegeneration, amyloid, helical, fibril, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 12 |
Total formula weight | 165567.43 |
Authors | Thacker, D.,Wilkinson, M.,Dewison, K.M.,Ranson, N.A.,Brockwell, D.J.,Radford, S.E. (deposition date: 2023-10-03, release date: 2024-09-04) |
Primary citation | Dewison, K.M.,Rowlinson, B.,Machin, J.M.,Crossley, J.A.,Thacker, D.,Wilkinson, M.,Ulamec, S.M.,Khan, G.N.,Ranson, N.A.,van Oosten-Hawle, P.,Brockwell, D.J.,Radford, S.E. Residues 2 to 7 of alpha-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways. Proc.Natl.Acad.Sci.USA, 121:e2315006121-e2315006121, 2024 Cited by PubMed: 39133842DOI: 10.1073/pnas.2315006121 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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