8PK4

Cryo EM structure of the type 5A polymorph of alpha-synuclein.

Summary for 8PK4

• Entry DOI: 10.2210/pdb8pk4/pdb
• Related: 8PIC 8PIX 8PJO 8PK2
• EMDB information: 17726
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: amyloid, polymorphism, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 145181.46

Authors

Frey, L.,Qureshi, B.M.,Kwiatkowski, W.,Rhyner, D.,Greenwald, J.,Riek, R. (deposition date: 2023-06-24, release date: 2024-05-29)

• Primary citation: Frey, L.,Ghosh, D.,Qureshi, B.M.,Rhyner, D.,Pokharna, A.,Guerrero-Ferreira, R.,Kwiatkowski, W.,Serdiuk, T.,Picotti, P.,Riek, R.,Greenwald, J.; On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation; Elife, 2023; DOI: 10.7554/eLife.93562.1

Experimental method

ELECTRON MICROSCOPY (3.3 Å)