8OQI

Cryo-EM structure of the wild-type alpha-synuclein fibril.

Summary for 8OQI

Entry DOI	10.2210/pdb8oqi/pdb
EMDB information	17111
Descriptor	Alpha-synuclein (1 entity in total)
Functional Keywords	alpha-synuclein, amyloid, fibril, parkinson's disease, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	10
Total formula weight	144761.08
Authors	Pesch, V.,Reithofer, S.,Ma, L.,Flores-Fernandez, J.M.,Oezduezenciler, P.,Busch, Y.,Lien, Y.,Rudtke, O.,Frieg, B.,Schroeder, G.F.,Wille, H.,Tamgueney, G. (deposition date: 2023-04-12, release date: 2024-03-13, Last modification date: 2024-05-15)
Primary citation	Pesch, V.,Flores-Fernandez, J.M.,Reithofer, S.,Ma, L.,Ozduzenciler, P.,Busch, Y.,Sriraman, A.,Wang, Y.,Amidian, S.,Kroepel, C.V.M.,Muller, L.,Lien, Y.,Rudtke, O.,Frieg, B.,Schroder, G.F.,Wille, H.,Tamguney, G. Vaccination with structurally adapted fungal protein fibrils induces immunity to Parkinson's disease. Brain, 147:1644-1652, 2024 Cited by PubMed: 38428032 DOI: 10.1093/brain/awae061 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation