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6TGK
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BU of 6tgk by Molmil
Domain swapped E6AP C-lobe dimer
Descriptor: ACETATE ION, CALCIUM ION, Ubiquitin-protein ligase E3A
Authors:Ries, L.K, Feiler, C, Lowe, L.D, Liess, A.K.L, Lorenz, S.
Deposit date:2019-11-16
Release date:2020-02-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP.
Protein Sci., 29, 2020
3H1D
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BU of 3h1d by Molmil
Structure of the HUWE1 HECT Domain
Descriptor: E3 ubiquitin-protein ligase HUWE1, SULFATE ION
Authors:Partridge, J.R, Schwartz, T.U.
Deposit date:2009-04-11
Release date:2009-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.
J.Biol.Chem., 285, 2010
3PT3
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BU of 3pt3 by Molmil
Crystal structure of the C-terminal lobe of the human UBR5 HECT domain
Descriptor: E3 ubiquitin-protein ligase UBR5
Authors:Matta-Camacho, E, Kozlov, G, Menade, M, Gehring, K.
Deposit date:2010-12-02
Release date:2012-01-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase.
Acta Crystallogr.,Sect.F, 68, 2012
9EQH
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BU of 9eqh by Molmil
WWP2 WW2-2,3-linker-HECT (WWP2-LH)
Descriptor: GLYCEROL, Isoform 2 of NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION
Authors:Dudey, A.P, Hemmings, A.M.
Deposit date:2024-03-21
Release date:2024-05-15
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases.
J Enzyme Inhib Med Chem, 39, 2024
5HPS
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BU of 5hps by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1 and UbV P1.1
Descriptor: Ubiquitin variant P1.1, WWP1 HECT
Authors:Wu, K.-P, Mercredi, P.Y, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
1ND7
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BU of 1nd7 by Molmil
Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase
Descriptor: WW domain-containing protein 1
Authors:Verdecia, M.A, Joaziero, C.A.P, Wells, N.J, Ferrer, J.-L, Bowman, M.E, Hunter, T, Noel, J.P.
Deposit date:2002-12-08
Release date:2003-09-23
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase
Mol.Cell, 11, 2003
1ZVD
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BU of 1zvd by Molmil
Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain
Descriptor: PHOSPHATE ION, SODIUM ION, Smad ubiquitination regulatory factor 2
Authors:Ogunjimi, A.A, Briant, D.J, Pece-Barbara, N, Le Roy, C, Di Guglielmo, G.M, Kavsak, P, Rasmussen, R.K, Seet, B.T, Sicheri, F, Wrana, J.L.
Deposit date:2005-06-01
Release date:2005-08-09
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT Domain.
Mol.Cell, 19, 2005
5W87
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BU of 5w87 by Molmil
Crystal structure of the C-terminal lobe of the human HERC6 HECT domain
Descriptor: PHOSPHATE ION, Probable E3 ubiquitin-protein ligase HERC6
Authors:WANG, Y, BELLESIS, A.G, ROYER, W.E, SPRATT, D.E.
Deposit date:2017-06-21
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Crystal structure of the C-terminal lobe of the human HERC6 HECT domain
To Be Published
2ONI
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BU of 2oni by Molmil
Catalytic Domain of the Human NEDD4-like E3 Ligase
Descriptor: E3 ubiquitin-protein ligase NEDD4-like protein, SODIUM ION
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2007-01-24
Release date:2007-04-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:NEDD4-like E3 Ubiquitin-protein Ligase
To be Published
8EI7
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BU of 8ei7 by Molmil
Crystal structure of the WWP2 HECT domain in complex with H304, a Helicon Polypeptide
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H.
Deposit date:2022-09-14
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
3TUG
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BU of 3tug by Molmil
Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Itchy homolog, UNKNOWN ATOM OR ION
Authors:Dong, A, Dobrovetsky, E, Xue, S, Butler, C, Wernimont, A, Walker, J.R, Tempel, W, Dhe-Paganon, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2011-09-16
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
To be Published
6J1X
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BU of 6j1x by Molmil
WWP1 close conformation
Descriptor: GLYCEROL, NEDD4-like E3 ubiquitin-protein ligase WWP1
Authors:Liu, Z.H.
Deposit date:2018-12-30
Release date:2019-07-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
6XZ1
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BU of 6xz1 by Molmil
Conjugate of the HECT domain of HUWE1 with ubiquitin
Descriptor: HECT, UBA and WWE domain containing 1, isoform CRA_a, ...
Authors:Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S.
Deposit date:2020-01-31
Release date:2021-08-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe.
Acs Chem.Biol., 16, 2021
5TJ8
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BU of 5tj8 by Molmil
Structure of WWP2 WW2-2,3-linker-HECT (no WW2 observed)
Descriptor: NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION
Authors:Chen, Z, Gabelli, S.B.
Deposit date:2016-10-03
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
5HPL
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BU of 5hpl by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: Rsp5 and UbV R5.4
Descriptor: Rsp5, Ubiquitin variant R5.4
Authors:Wu, K.-P, Kamadurai, H.B, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
7QPB
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BU of 7qpb by Molmil
Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle
Descriptor: Isoform I of Ubiquitin-protein ligase E3A, hybrid foldamer-peptide macrocycle
Authors:Dengler, S, Howard, R.T, Morozov, V, Tsiamantas, C, Douat, C, Suga, H, Huc, I.
Deposit date:2022-01-03
Release date:2023-09-27
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.342 Å)
Cite:Display Selection of a Hybrid Foldamer-Peptide Macrocycle.
Angew.Chem.Int.Ed.Engl., 62, 2023
6JX5
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BU of 6jx5 by Molmil
Hect domain of AREL1
Descriptor: Apoptosis-resistant E3 ubiquitin protein ligase 1
Authors:Sivaraman, J, Singh, S, Ng, J, Nayak, D.
Deposit date:2019-04-22
Release date:2019-12-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activitiesin vitro.
J.Biol.Chem., 294, 2019
8EI4
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BU of 8ei4 by Molmil
Crystal structure of the WWP1 HECT domain in complex with H302, a Helicon Polypeptide
Descriptor: 1,2-ETHANEDIOL, H302, N,N'-(1,4-phenylene)diacetamide, ...
Authors:Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H.
Deposit date:2022-09-14
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
5HPK
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BU of 5hpk by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1
Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1
Authors:Wu, K.-P, Mukherjee, M, Mercredi, P.Y, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5C91
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BU of 5c91 by Molmil
NEDD4 HECT with covalently bound indole-based inhibitor
Descriptor: E3 ubiquitin-protein ligase NEDD4, methyl (2E)-4-{[(5-methoxy-1,2-dimethyl-1H-indol-3-yl)carbonyl]amino}but-2-enoate
Authors:Span, I, Smith, A.T, Kathman, S, Statsyuk, A.V, Rosenzweig, A.C.
Deposit date:2015-06-26
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism.
J. Am. Chem. Soc., 137, 2015
3OLM
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BU of 3olm by Molmil
Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase
Descriptor: E3 ubiquitin-protein ligase RSP5, Ubiquitin
Authors:Kim, H.C, Steffen, A, Chen, J, Huibregtse, J.M.
Deposit date:2010-08-26
Release date:2011-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structure and function of a HECT domain ubiquitin-binding site.
Embo Rep., 12, 2011
6FX4
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BU of 6fx4 by Molmil
Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C
Descriptor: E3 ubiquitin-protein ligase SMURF2, GLYCEROL, Polyubiquitin-B
Authors:Jaeckl, M, Holdermann, I, Wiesner, S.
Deposit date:2018-03-08
Release date:2018-07-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.
J. Mol. Biol., 430, 2018
7M3Q
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BU of 7m3q by Molmil
Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, ...
Authors:Chowdhury, A, Singer, A.U, Ogunjimi, A.A, Teyra, J, Zhang, W, Sicheri, F, Sidhu, S.S.
Deposit date:2021-03-18
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
To be published
2XBF
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BU of 2xbf by Molmil
Nedd4 HECT structure
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE NEDD4
Authors:Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S.
Deposit date:2010-04-09
Release date:2011-03-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
4Y07
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BU of 4y07 by Molmil
Crystal structure of the HECT domain of human WWP2
Descriptor: NEDD4-like E3 ubiquitin-protein ligase WWP2
Authors:Gong, W, Li, J, Li, Z, Xu, Y.
Deposit date:2015-02-05
Release date:2015-11-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.507 Å)
Cite:Structure of the HECT domain of human WWP2
Acta Crystallogr.,Sect.F, 71, 2015

 

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