5C91

NEDD4 HECT with covalently bound indole-based inhibitor

Summary for 5C91

Entry DOI	10.2210/pdb5c91/pdb
Related	2XBB 2XBF
Descriptor	E3 ubiquitin-protein ligase NEDD4, methyl (2E)-4-{[(5-methoxy-1,2-dimethyl-1H-indol-3-yl)carbonyl]amino}but-2-enoate (3 entities in total)
Functional Keywords	nedd4, hect, ligase, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P46934
Total number of polymer chains	1
Total formula weight	45055.38
Authors	Span, I.,Smith, A.T.,Kathman, S.,Statsyuk, A.V.,Rosenzweig, A.C. (deposition date: 2015-06-26, release date: 2015-09-30, Last modification date: 2023-09-27)
Primary citation	Kathman, S.G.,Span, I.,Smith, A.T.,Xu, Z.,Zhan, J.,Rosenzweig, A.C.,Statsyuk, A.V. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J. Am. Chem. Soc., 137:12442-12445, 2015 Cited by PubMed: 26371805 DOI: 10.1021/jacs.5b06839 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation