1E6I
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BROMODOMAIN FROM GCN5 COMPLEXED WITH ACETYLATED H4 PEPTIDE
Descriptor:TRANSCRIPTIONAL ACTIVATOR GCN5, HISTONE H4
Authors:Owen, D.J., Travers, A.A., Evans, P.R.
Deposit date:2000-08-18
Release date:2000-11-24
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Structural Basis for the Recognition of Acetylated Histone H4 by the Bromodomain of Histone Acetyltransferase Gcn5P
Embo J., 19, 2000
1EQF
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CRYSTAL STRUCTURE OF THE DOUBLE BROMODOMAIN MODULE FROM HUMAN TAFII250
Descriptor:RNA POLYMERASE II TRANSCRIPTION INITIATION FACTOR, SULFATE ION
Authors:Jacobson, R.H., Ladurner, A.G., King, D.S., Tjian, R.
Deposit date:2000-04-04
Release date:2000-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of a human TAFII250 double bromodomain module.
Science, 288, 2000
1F68
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NMR SOLUTION STRUCTURE OF THE BROMODOMAIN FROM HUMAN GCN5
Descriptor:HISTONE ACETYLTRANSFERASE
Authors:Wright, P.E., Hudson, B.P., Dyson, H.J.
Deposit date:2000-06-20
Release date:2000-12-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain.
J.Mol.Biol., 304, 2000
1JM4
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NMR STRUCTURE OF P/CAF BROMODOMAIN IN COMPLEX WITH HIV-1 TAT PEPTIDE
Descriptor:HIV-1 Tat Peptide, P300/CBP-associated Factor
Authors:Mujtaba, S., He, Y., Zeng, L., Farooq, A., Carlson, J.E., Ott, M., Verdin, E., Zhou, M.-M.
Deposit date:2001-07-17
Release date:2002-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
Mol.Cell, 9, 2002
1JSP
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NMR STRUCTURE OF CBP BROMODOMAIN IN COMPLEX WITH P53 PEPTIDE
Descriptor:tumor protein p53, CREB-BINDING PROTEIN
Authors:He, Y., Mujtaba, S., Zeng, L., Yan, S., Zhou, M.-M.
Deposit date:2001-08-17
Release date:2002-08-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
1N72
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STRUCTURE AND LIGAND OF A HISTONE ACETYLTRANSFERASE BROMODOMAIN
Descriptor:HISTONE ACETYLTRANSFERASE
Authors:Dhalluin, C., Carlson, J.E., Zeng, L., He, C., Aggarwal, A.K., Zhou, M.-M.
Deposit date:2002-11-12
Release date:2002-12-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Ligand of a Histone Acetyltransferase Bromodomain
Nature, 399, 1999
1WUG
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COMPLEX STRUCTURE OF PCAF BROMODOMAIN WITH SMALL CHEMICAL LIGAND NP1
Descriptor:Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE
Authors:Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M.
Deposit date:2004-12-07
Release date:2005-08-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1WUM
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COMPLEX STRUCTURE OF PCAF BROMODOMAIN WITH SMALL CHEMICAL LIGAND NP2
Descriptor:Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Authors:Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M.
Deposit date:2004-12-08
Release date:2005-08-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1X0J
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CRYSTAL STRUCTURE ANALYSIS OF THE N-TERMINAL BROMODOMAIN OF HUMAN BRD2
Descriptor:Bromodomain-containing protein 2, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Nakamura, Y., Umehara, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-03-23
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for acetylated histone H4 recognition by the human Brd2 bromodomain
To be Published
1ZS5
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STRUCTURE-BASED EVALUATION OF SELECTIVE AND NON-SELECTIVE SMALL MOLECULES THAT BLOCK HIV-1 TAT AND PCAF ASSOCIATION
Descriptor:Histone acetyltransferase PCAF, (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
Authors:Zeng, L., Godbole, S., Muller, M., Yan, S., Sanchez, R., Zhou, M.
Deposit date:2005-05-23
Release date:2006-05-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-based evaluation of selective nad non-selective small molecules that block hiv-1 tat and pcaf association
TO BE PUBLISHED
2D82
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TARGET STRUCTURE-BASED DISCOVERY OF SMALL MOLECULES THAT BLOCK HUMAN P53 AND CREB BINDING PROTEIN (CBP) ASSOCIATION
Descriptor:CREB-binding protein, 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Authors:Sachchidanand, Resnick-Silverman, L., Yan, S., Mujtaba, S., Liu, W.J., Zeng, L., Manfredi, J.J., Zhou, M.M.
Deposit date:2005-12-01
Release date:2006-04-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Target structure-based discovery of small molecules that block human p53 and CREB binding protein association
Chem.Biol., 13, 2006
2D9E
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SOLUTION STRUCTURE OF THE BROMODOMAIN OF PEREGRIN
Descriptor:Peregrin
Authors:Hatta, R., Hayashi, F., Izumi, K., Yoshida, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-09
Release date:2006-06-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Bromodomain of Peregrin
To be published
2DKW
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SOLUTION STRUCTURE OF THE BROMODOMAIN OF HUMAN PROTEIN KIAA1240
Descriptor:hypothetical protein KIAA1240
Authors:Sano, R., Hayashi, F., Kurosaki, C., Yoshida, M., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-04-14
Release date:2006-10-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the bromodomain of human protein KIAA1240
To be Published
2DVQ
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CRYSTAL STRUCTURE ANALYSIS OF THE N-TERMINAL BROMODOMAIN OF HUMAN BRD2 COMPLEXED WITH ACETYLATED HISTONE H4 PEPTIDE
Descriptor:Bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y., Umehara, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
2DVR
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CRYSTAL STRUCTURE ANALYSIS OF THE N-TERMINAL BROMODOMAIN OF HUMAN BRD2 COMPLEXED WITH ACETYLATED HISTONE H4 PEPTIDE
Descriptor:bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y., Umehara, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
2DVS
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CRYSTAL STRUCTURE ANALYSIS OF THE N-TERMINAL BROMODOMAIN OF HUMAN BRD2 COMPLEXED WITH ACETYLATED HISTONE H4 PEPTIDE
Descriptor:bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y., Umehara, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
2DVV
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF THE HUMAN BRD2 PROTEIN
Descriptor:Bromodomain-containing protein 2, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the second bromodomain of the human Brd2 protein
To be Published
2DWW
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CRYSTAL STRUCTURE OF BROMODOMAIN-CONTAINING PROTEIN 4
Descriptor:Bromodomain-containing protein 4, CHLORIDE ION
Authors:Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-21
Release date:2007-08-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of Bromodomain-containing protein 4
To be Published
2E3K
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CRYSTAL STRUCTURE OF THE HUMAN BRD2 SECOND BROMODOMAIN IN COMPLEXED WITH THE ACETYLATED HISTONE H4 PEPTIDE
Descriptor:Bromodomain-containing protein 2, 15-mer peptide from Histone H4
Authors:Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-11-27
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for diacetylated histone H4 tail recognition by the second bromodomain of human BRD2
To be Published
2E7N
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SOLUTION STRUCTURE OF THE SECOND BROMODOMAIN FROM HUMAN BROMODOMAIN-CONTAINING PROTEIN 3
Descriptor:Bromodomain-containing protein 3
Authors:Qin, X.R., Kurosaki, C., Hayashi, F., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-01-11
Release date:2007-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the second Bromodomain from human Bromodomain-containing protein 3
to be published
2E7O
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SOLUTION STRUCTURE OF THE BROMODOMAIN FROM HUMAN BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN 2B
Descriptor:Bromodomain adjacent to zinc finger domain 2B
Authors:Qin, X.R., Kurosaki, C., Hayashi, F., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-01-11
Release date:2007-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Bromodomain from human Bromodomain adjacent to zinc finger domain 2B
to be published
2G4A
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SOLUTION STRUCTURE OF A BROMODOMAIN FROM RING3 PROTEIN
Descriptor:Bromodomain-containing protein 2
Authors:Huang, H., Wu, J., Shi, Y.
Deposit date:2006-02-21
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a Bromodomain from RING3
to be published
2GRC
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1.5 A STRUCTURE OF BROMODOMAIN FROM HUMAN BRG1 PROTEIN, A CENTRAL ATPASE OF SWI/SNF REMODELING COMPLEX
Descriptor:Probable global transcription activator SNF2L4
Authors:Singh, M., Popowicz, G.M., Krajewski, M., Holak, T.A.
Deposit date:2006-04-24
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
Chembiochem, 8, 2007
2H60
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SOLUTION STRUCTURE OF HUMAN BRG1 BROMODOMAIN
Descriptor:Probable global transcription activator SNF2L4
Authors:Shen, W., Xu, C., Zhang, J., Wu, J., Shi, Y.
Deposit date:2006-05-30
Release date:2007-02-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails
Biochemistry, 46, 2007
2I7K
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SOLUTION STRUCTURE OF THE BROMODOMAIN OF HUMAN BRD7 PROTEIN
Descriptor:Bromodomain-containing protein 7
Authors:Sun, H., Liu, J., Zhang, J., Huang, H., Wu, J., Shi, Y.
Deposit date:2006-08-31
Release date:2007-07-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4
Biochem.Biophys.Res.Commun., 358, 2007
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