4UYD
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1,3-dimethyl-2-oxo-2,3- dihydro-1H-1,3-benzodiazole-5-carboxamide
Summary for 4UYD
Entry DOI | 10.2210/pdb4uyd/pdb |
Related | 4UYE 4UYF 4UYG 4UYH |
Descriptor | BROMODOMAIN-CONTAINING PROTEIN 4, DIMETHYL SULFOXIDE, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | transcription, inhibitor, histone, epigenetic reader, antagonist |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 18307.00 |
Authors | Chung, C.,Bamborough, P.,Demont, E. (deposition date: 2014-08-30, release date: 2014-09-17, Last modification date: 2024-05-08) |
Primary citation | Demont, E.H.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Fallon, D.,Gordon, L.J.,Grandi, P.,Hobbs, C.I.,Hussain, J.,Jones, E.J.,Le Gall, A.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Roberts, A.D.,Sheppard, R.J.,Watson, R.J. 1,3-Dimethyl Benzimidazolones are Potent, Selective Inhibitors of the Brpf1 Bromodomain. Acs Med.Chem.Lett., 5:1190-, 2014 Cited by PubMed: 25408830DOI: 10.1021/ML5002932 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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