4UYD

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1,3-dimethyl-2-oxo-2,3- dihydro-1H-1,3-benzodiazole-5-carboxamide

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 1169

Chain	Residue
A	TRP81
A	LYS99
A	HOH2235
A	HOH2236

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1170

Chain	Residue
A	HOH2184
A	HOH2275
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135

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site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE V1T A 1171

Chain	Residue
A	TRP81
A	PRO82
A	GLN85
A	VAL87
A	LEU92
A	ASN140
A	HOH2131
A	HOH2144
A	HOH2171
A	HOH2175

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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