Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4UYG

C-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A)

Summary for 4UYG
Entry DOI10.2210/pdb4uyg/pdb
Related4UYD 4UYE 4UYF 4UYH
DescriptorBROMODOMAIN-CONTAINING PROTEIN 2, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid, SULFATE ION, ... (4 entities in total)
Functional Keywordstranscription, inhibitor, histone, epigenetic reader, bet, brd2
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus : P25440
Total number of polymer chains6
Total formula weight110553.17
Authors
Chung, C.,Bamborough, P.,Gosmini, R. (deposition date: 2014-08-31, release date: 2014-10-08, Last modification date: 2014-10-22)
Primary citationGosmini, R.,Nguyen, V.L.,Toum, J.,Simon, C.,Brusq, J.M.,Krysa, G.,Mirguet, O.,Riou-Eymard, A.M.,Boursier, E.V.,Trottet, L.,Bamborough, P.,Clark, H.,Chung, C.W.,Cutler, L.,Demont, E.H.,Kaur, R.,Lewis, A.J.,Schilling, M.B.,Soden, P.E.,Taylor, S.,Walker, A.L.,Walker, M.D.,Prinjha, R.K.,Nicodeme, E.
The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor.
J.Med.Chem., 57:8111-, 2014
Cited by
PubMed: 25249180
DOI: 10.1021/JM5010539
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon