4UYG

C-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	BROMODOMAIN-CONTAINING PROTEIN 2	polymer	157	17942.6	6	UniProt (P25440) Pfam (PF00439)	HOMO SAPIENS (HUMAN)	O27.1.1, REALLY INTERESTING NEW GENE 3 PROTEIN
2	G, J, K, M, N... (A, B, C, D, E...)	4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid	non-polymer		434.9	6	Chemie (73B)
3	H, I, L (A, C)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	P, Q, R, S, T... (A, B, C, D, E...)	water	water		18.0	243	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 338 - 473 (UniProt: P25440)

PDB	External Database	Details
Met 317	-	expression tag
Gly 318	-	expression tag
Ser 319	-	expression tag
Ser 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
Ser 327	-	expression tag
Ser 328	-	expression tag
Gly 329	-	expression tag
Leu 330	-	expression tag
Val 331	-	expression tag
Pro 332	-	expression tag
Arg 333	-	expression tag
Gly 334	-	expression tag
Ser 335	-	expression tag
His 336	-	expression tag
Met 337	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	107655.5
Non-Polymers*	Number of molecules	9
	Total formula weight	2897.7
All*	Total formula weight	110553.2

*Water molecules are not included.