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4UYG

C-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A)

Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 73B A 1456
ChainResidue
ATRP370
APRO371
ALEU381
ALEU383
ACYS425
AASN429
AVAL435
AHOH2029

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 73B B 1456
ChainResidue
BPRO371
BPHE372
BLEU383
BCYS425
BASN429
BHOH2022
BHOH2045
BTRP370

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 73B C 1456
ChainResidue
CTRP370
CPRO371
CPHE372
CLEU383
CCYS425
CASN429
CHIS433
CVAL435
CHOH2027
CHOH2051
CHOH2052

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 73B D 1456
ChainResidue
DTRP370
DPRO371
DLEU381
DLEU383
DCYS425
DASN429
DHIS433
DHOH2019
DHOH2033

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 73B E 1456
ChainResidue
EPRO371
ELEU381
ELEU383
ECYS425
EASN429
EVAL435
EHOH2010
EHOH2019

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 73B F 1456
ChainResidue
FPRO371
FPHE372
FVAL376
FLEU381
FLEU383
FASN429
FVAL435

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1457
ChainResidue
AVAL376
AASP377
AALA378
ASER379
AHIS387

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 C 1457
ChainResidue
CSER362
CLYS363
CHOH2014

site_idAC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SO4 A 1458
ChainResidue
AARG401

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY
ChainResidueDetails
AALA369-TYR428

226707

PDB entries from 2024-10-30

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