1WUM
Complex structure of PCAF bromodomain with small chemical ligand NP2
Summary for 1WUM
| Entry DOI | 10.2210/pdb1wum/pdb |
| Related | 1JM4 1WUG 1b91 |
| NMR Information | BMRB: 6507 |
| Descriptor | Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE (2 entities in total) |
| Functional Keywords | bromodomain, histone-acetyltransferase, nmr-structure, chemical ligand, np2, np1, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus (By similarity): Q92831 |
| Total number of polymer chains | 1 |
| Total formula weight | 14247.44 |
| Authors | Zeng, L.,Li, J.,Muller, M.,Yan, S.,Mujtaba, S.,Pan, C.,Wang, Z.,Zhou, M.M. (deposition date: 2004-12-08, release date: 2005-08-16, Last modification date: 2024-05-29) |
| Primary citation | Zeng, L.,Li, J.,Muller, M.,Yan, S.,Mujtaba, S.,Pan, C.,Wang, Z.,Zhou, M.M. Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127:2376-2377, 2005 Cited by PubMed Abstract: Development of drug resistance from mutations in the targeted viral proteins leads to continuation of viral production by chronically infected cells, contributing to HIV-mediated immune dysfunction. Targeting a host cell protein essential for viral reproduction, rather than a viral protein, may minimize the viral drug resistance problem as observed with HIV protease inhibitors. We report here the development of a novel class of N1-aryl-propane-1,3-diamine compounds using a structure-based approach that selectively inhibit the activity of the bromodomain of the human transcriptional co-activator PCAF, of which association with the HIV trans-activator Tat is essential for transcription and replication of the integrated HIV provirus. PubMed: 15724976DOI: 10.1021/ja044885g PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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