4WHW
Direct photocapture of bromodomains using tropolone chemical probes
Summary for 4WHW
Entry DOI | 10.2210/pdb4whw/pdb |
Descriptor | Bromodomain-containing protein 4, 2-methoxy-4-{1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl}cyclohepta-2,4,6-trien-1-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromo domain, brd4, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15631.02 |
Authors | Hett, E.C.,Piatnitski Chekler, E.L.,Basak, A.,Bonin, P.D.,Denny, R.A.,Flick, A.C.,Geoghegan, K.F.,Liu, S.,Pletcher, M.T.,Robinson, R.P.,Sahasrabudhe, P.,Salter, S.,Stock, I.A.,Jones, L.H. (deposition date: 2014-09-23, release date: 2015-10-28, Last modification date: 2023-12-27) |
Primary citation | Hett, E.C.,Piatnitski Chekler, E.L.,Basak, A.,Bonin, P.D.,Denny, R.A.,Flick, A.C.,Geoghegan, K.F.,Liu, S.,Pletcher, M.T.,Robinson, R.P.,Sahasrabudhe, P.,Salter, S.,Stock, I.A.,Jones, L.H. Direct photocapture of bromodomains using tropolone chemical probes To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.345 Å) |
Structure validation
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