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8Y2F
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BU of 8y2f by Molmil
Cryo-EM structure of human dopamine transporter in complex with GBR12909
Descriptor: 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent dopamine transporter
Authors:Zhao, Y, Li, Y.
Deposit date:2024-01-25
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.
Nature, 632, 2024
8Y2D
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BU of 8y2d by Molmil
Cryo-EM structure of human dopamine transporter in complex with dopamine
Descriptor: CHLORIDE ION, L-DOPAMINE, SODIUM ION, ...
Authors:Zhao, Y, Li, Y.
Deposit date:2024-01-25
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.
Nature, 632, 2024
8Y2C
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BU of 8y2c by Molmil
Cryo-EM structure of human dopamine transporter in apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent dopamine transporter
Authors:Zhao, Y, Li, Y.
Deposit date:2024-01-25
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.
Nature, 632, 2024
8Y2E
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BU of 8y2e by Molmil
Cryo-EM structure of human dopamine transporter in complex with benztropine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent dopamine transporter, benztropine
Authors:Zhao, Y, Li, Y.
Deposit date:2024-01-25
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.
Nature, 632, 2024
8Y2G
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BU of 8y2g by Molmil
Cryo-EM structure of human dopamine transporter in complex with methylphenidate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SODIUM ION, ...
Authors:Zhao, Y, Li, Y.
Deposit date:2024-01-25
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.
Nature, 632, 2024
8WTW
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BU of 8wtw by Molmil
Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue
Descriptor: CHLORIDE ION, MrlA, O-methyl-L-tyrosine, ...
Authors:Zhao, Y, Hu, T, Yu, Z.
Deposit date:2023-10-19
Release date:2024-08-07
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
8WTU
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BU of 8wtu by Molmil
Cryo-EM structure of noradrenaline transporter in apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent noradrenaline transporter
Authors:Zhao, Y, Hu, T, Yu, Z.
Deposit date:2023-10-19
Release date:2024-08-07
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
8WTX
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BU of 8wtx by Molmil
Cryo-EM structure of noradrenaline transporter in complex with bupropion
Descriptor: (2~{R})-2-(~{tert}-butylamino)-1-(3-chlorophenyl)propan-1-one, Sodium-dependent noradrenaline transporter
Authors:Zhao, Y, Hu, T, Yu, Z.
Deposit date:2023-10-19
Release date:2024-08-07
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
8WTY
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BU of 8wty by Molmil
Cryo-EM structure of noradrenaline transporter in complex with ziprasidone
Descriptor: 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloranyl-1,3-dihydroindol-2-one, Sodium-dependent noradrenaline transporter
Authors:Zhao, Y, Hu, T, Yu, Z.
Deposit date:2023-10-19
Release date:2024-08-07
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
8WTV
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BU of 8wtv by Molmil
Cryo-EM structure of noradrenaline transporter in complex with noradrenaline
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Noradrenaline, ...
Authors:Zhao, Y, Hu, T, Yu, Z.
Deposit date:2023-10-19
Release date:2024-08-07
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
8VBY
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BU of 8vby by Molmil
Structure of the human dopamine transporter in complex with beta-CFT, MRS7292 and divalent zinc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, DECANE, ...
Authors:Srivastava, D.K, Gouaux, E.
Deposit date:2023-12-12
Release date:2024-08-07
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structure of the human dopamine transporter and mechanisms of inhibition.
Nature, 632, 2024
8WGX
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BU of 8wgx by Molmil
Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with norepinephrine in nanodisc.
Descriptor: L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter
Authors:Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
Deposit date:2023-09-22
Release date:2024-07-31
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
8WGR
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BU of 8wgr by Molmil
Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with antidepressant desipramine in KCl condition.
Descriptor: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, POTASSIUM ION, ...
Authors:Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
Deposit date:2023-09-22
Release date:2024-07-31
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
8Z1L
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BU of 8z1l by Molmil
Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant atomoxetine in an outward-open state at resolution of 3.4 angstrom.
Descriptor: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine, CHLORIDE ION, Sodium-dependent noradrenaline transporter
Authors:Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
Deposit date:2024-04-11
Release date:2024-07-31
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
9EUO
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BU of 9euo by Molmil
Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive inhibitor
Descriptor: 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A.
Deposit date:2024-03-27
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
J.Neurochem., 2024
9EUP
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BU of 9eup by Molmil
Inhibitor-free outward-open structure of Drosophila dopamine transporter
Descriptor: 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A.
Deposit date:2024-03-27
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
J.Neurochem., 2024
8XB2
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BU of 8xb2 by Molmil
Structure of radafaxine-bound state of the human Norepinephrine Transporter
Descriptor: (2~{S},3~{S})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholin-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter
Authors:Wu, J.X, Ji, W.M.
Deposit date:2023-12-05
Release date:2024-07-10
Last modified:2024-09-18
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Substrate binding and inhibition mechanism of norepinephrine transporter.
Nature, 2024
8I3V
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BU of 8i3v by Molmil
Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom.
Descriptor: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, Sodium-dependent noradrenaline transporter
Authors:Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
Deposit date:2023-01-18
Release date:2024-07-03
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
9EO4
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BU of 9eo4 by Molmil
Outward-open structure of human dopamine transporter bound to cocaine
Descriptor: CHLORIDE ION, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ...
Authors:Nielsen, J.C, Salomon, K, Kalenderoglou, I.E, Bargmeyer, S, Pape, T, Shahsavar, A, Loland, C.J.
Deposit date:2024-03-14
Release date:2024-07-03
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structure of the human dopamine transporter in complex with cocaine.
Nature, 632, 2024
8XB3
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BU of 8xb3 by Molmil
Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter
Descriptor: 1-[(3-iodanylphenyl)methyl]guanidine, 2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2
Authors:Ji, W.M, Wu, J.X.
Deposit date:2023-12-05
Release date:2024-06-26
Last modified:2024-09-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Substrate binding and inhibition mechanism of norepinephrine transporter.
Nature, 2024
8XB4
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BU of 8xb4 by Molmil
Structure of apo state of the human Norepinephrine Transporter
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2
Authors:Wu, J.X, Ji, W.M.
Deposit date:2023-12-05
Release date:2024-06-26
Last modified:2024-09-18
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Substrate binding and inhibition mechanism of norepinephrine transporter.
Nature, 2024
8P2Y
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BU of 8p2y by Molmil
Structure of human SIT1:ACE2 complex (closed PD conformation)
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B.
Deposit date:2023-05-16
Release date:2024-06-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
8P31
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BU of 8p31 by Molmil
Structure of human SIT1:ACE2 complex (closed PD conformation) bound to L-pipecolate
Descriptor: (2S)-piperidine-2-carboxylic acid, 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B.
Deposit date:2023-05-16
Release date:2024-06-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
8P2X
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BU of 8p2x by Molmil
Structure of human SIT1:ACE2 complex (open PD conformation)
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B.
Deposit date:2023-05-16
Release date:2024-06-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
8P2W
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BU of 8p2w by Molmil
Structure of human SIT1 (focussed map / refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Sodium- and chloride-dependent transporter XTRP3
Authors:Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B.
Deposit date:2023-05-16
Release date:2024-06-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024

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PDB entries from 2024-09-18

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