8Y2F
 
 | | Cryo-EM structure of human dopamine transporter in complex with GBR12909 | | Descriptor: | 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent dopamine transporter | | Authors: | Zhao, Y, Li, Y. | | Deposit date: | 2024-01-25 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.
Nature, 632, 2024
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8Y2D
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8Y2C
 | | Cryo-EM structure of human dopamine transporter in apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent dopamine transporter | | Authors: | Zhao, Y, Li, Y. | | Deposit date: | 2024-01-25 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.
Nature, 632, 2024
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8Y2E
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8Y2G
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8WTW
 | | Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue | | Descriptor: | CHLORIDE ION, MrlA, O-methyl-L-tyrosine, ... | | Authors: | Zhao, Y, Hu, T, Yu, Z. | | Deposit date: | 2023-10-19 | | Release date: | 2024-08-07 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8WTU
 | | Cryo-EM structure of noradrenaline transporter in apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent noradrenaline transporter | | Authors: | Zhao, Y, Hu, T, Yu, Z. | | Deposit date: | 2023-10-19 | | Release date: | 2024-08-07 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8WTX
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8WTY
 | | Cryo-EM structure of noradrenaline transporter in complex with ziprasidone | | Descriptor: | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloranyl-1,3-dihydroindol-2-one, Sodium-dependent noradrenaline transporter | | Authors: | Zhao, Y, Hu, T, Yu, Z. | | Deposit date: | 2023-10-19 | | Release date: | 2024-08-07 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8WTV
 | | Cryo-EM structure of noradrenaline transporter in complex with noradrenaline | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Noradrenaline, ... | | Authors: | Zhao, Y, Hu, T, Yu, Z. | | Deposit date: | 2023-10-19 | | Release date: | 2024-08-07 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter.
Nature, 632, 2024
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8VBY
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8WGX
 | | Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with norepinephrine in nanodisc. | | Descriptor: | L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter | | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | | Deposit date: | 2023-09-22 | | Release date: | 2024-07-31 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
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8WGR
 | | Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with antidepressant desipramine in KCl condition. | | Descriptor: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, POTASSIUM ION, ... | | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | | Deposit date: | 2023-09-22 | | Release date: | 2024-07-31 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
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8Z1L
 | | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant atomoxetine in an outward-open state at resolution of 3.4 angstrom. | | Descriptor: | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine, CHLORIDE ION, Sodium-dependent noradrenaline transporter | | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | | Deposit date: | 2024-04-11 | | Release date: | 2024-07-31 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
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9EUO
 | | Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive inhibitor | | Descriptor: | 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ... | | Authors: | Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A. | | Deposit date: | 2024-03-27 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
J.Neurochem., 2024
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9EUP
 | | Inhibitor-free outward-open structure of Drosophila dopamine transporter | | Descriptor: | 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ... | | Authors: | Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A. | | Deposit date: | 2024-03-27 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.
J.Neurochem., 2024
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8XB2
 | | Structure of radafaxine-bound state of the human Norepinephrine Transporter | | Descriptor: | (2~{S},3~{S})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholin-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter | | Authors: | Wu, J.X, Ji, W.M. | | Deposit date: | 2023-12-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Substrate binding and inhibition mechanism of norepinephrine transporter.
Nature, 2024
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8I3V
 | | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom. | | Descriptor: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, Sodium-dependent noradrenaline transporter | | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | | Deposit date: | 2023-01-18 | | Release date: | 2024-07-03 | | Last modified: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 632, 2024
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9EO4
 | | Outward-open structure of human dopamine transporter bound to cocaine | | Descriptor: | CHLORIDE ION, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Nielsen, J.C, Salomon, K, Kalenderoglou, I.E, Bargmeyer, S, Pape, T, Shahsavar, A, Loland, C.J. | | Deposit date: | 2024-03-14 | | Release date: | 2024-07-03 | | Last modified: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structure of the human dopamine transporter in complex with cocaine.
Nature, 632, 2024
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8XB3
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8XB4
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8P2Y
 | | Structure of human SIT1:ACE2 complex (closed PD conformation) | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B. | | Deposit date: | 2023-05-16 | | Release date: | 2024-06-12 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
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8P31
 | | Structure of human SIT1:ACE2 complex (closed PD conformation) bound to L-pipecolate | | Descriptor: | (2S)-piperidine-2-carboxylic acid, 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B. | | Deposit date: | 2023-05-16 | | Release date: | 2024-06-12 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
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8P2X
 | | Structure of human SIT1:ACE2 complex (open PD conformation) | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B. | | Deposit date: | 2023-05-16 | | Release date: | 2024-06-12 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
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8P2W
 | | Structure of human SIT1 (focussed map / refinement) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Sodium- and chloride-dependent transporter XTRP3 | | Authors: | Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B. | | Deposit date: | 2023-05-16 | | Release date: | 2024-06-12 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
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