9EUO

Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive inhibitor

This is a non-PDB format compatible entry.

Summary for 9EUO

• Entry DOI: 10.2210/pdb9euo/pdb
• Related: 9EUP
• EMDB information: 19978 19979
• Descriptor: Sodium-dependent dopamine transporter, 9D5 ANTIBODY, LIGHT CHAIN, 9D5 ANTIBODY, HEAVY CHAIN, ... (9 entities in total)
• Functional Keywords: slc6a3, dopamine transporter, atypical inhibitors, neurotransmitter sodium symporters, membrane protein
• Biological source: Drosophila melanogaster (fruit fly); More
• Total number of polymer chains: 3
• Total formula weight: 114089.29

Authors

Pedersen, C.N.,Yang, F.,Ita, S.,Xu, Y.,Akunuri, R.,Trampari, S.,Neumann, C.M.T.,Desdorf, L.M.,Schioett, B.,Salvino, J.M.,Mortensen, O.V.,Nissen, P.,Shahsavar, A. (deposition date: 2024-03-27, release date: 2024-07-24)

• Primary citation: Pedersen, C.N.,Yang, F.,Ita, S.,Xu, Y.,Akunuri, R.,Trampari, S.,Neumann, C.M.T.,Desdorf, L.M.,Schiott, B.,Salvino, J.M.,Mortensen, O.V.,Nissen, P.,Shahsavar, A.; Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.; J.Neurochem., 2024; PubMed: 39010681; DOI: 10.1111/jnc.16179

Experimental method

ELECTRON MICROSCOPY (3.2 Å)