9EUO
Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive inhibitor
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sodium-dependent dopamine transporter | polymer | 543 | 60939.5 | 1 | UniProt (Q7K4Y6) Pfam (PF00209) In PDB | Drosophila melanogaster (fruit fly) | Protein fumin |
2 | L | 9D5 ANTIBODY, LIGHT CHAIN | polymer | 237 | 25840.6 | 1 | Mus musculus | ||
3 | H | 9D5 ANTIBODY, HEAVY CHAIN | polymer | 240 | 25921.3 | 1 | Mus musculus | ||
4 | A | N-[3-(6-chloranyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)propyl]butanamide | non-polymer | 333.9 | 1 | Chemie (A1H8F) | |||
5 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) | |||
6 | A | TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | non-polymer | 122.1 | 1 | Chemie (144) | |||
7 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
8 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
9 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) |
Sequence modifications
A: 21 - 601 (UniProt: Q7K4Y6)
PDB | External Database | Details |
---|---|---|
Met 20 | - | initiating methionine |
Ala 74 | Val 74 | engineered mutation |
- | Asn 164 | deletion |
- | Ala 165 | deletion |
- | Ser 166 | deletion |
- | Arg 167 | deletion |
- | Val 168 | deletion |
- | Pro 169 | deletion |
- | Val 170 | deletion |
- | Ile 171 | deletion |
- | Gly 172 | deletion |
- | Asn 173 | deletion |
- | Tyr 174 | deletion |
- | Ser 175 | deletion |
- | Asp 176 | deletion |
- | Leu 177 | deletion |
- | Tyr 178 | deletion |
- | Ala 179 | deletion |
- | Met 180 | deletion |
- | Gly 181 | deletion |
- | Asn 182 | deletion |
- | Gln 183 | deletion |
- | Ser 184 | deletion |
- | Leu 185 | deletion |
- | Leu 186 | deletion |
- | Tyr 187 | deletion |
- | Asn 188 | deletion |
- | Glu 189 | deletion |
- | Thr 190 | deletion |
- | Tyr 191 | deletion |
- | Met 192 | deletion |
- | Asn 193 | deletion |
- | Gly 194 | deletion |
- | Ser 195 | deletion |
- | Ser 196 | deletion |
- | Leu 197 | deletion |
- | Asp 198 | deletion |
- | Thr 199 | deletion |
- | Ser 200 | deletion |
- | Ala 201 | deletion |
- | Val 202 | deletion |
- | Gly 203 | deletion |
- | His 204 | deletion |
- | Val 205 | deletion |
- | Glu 206 | deletion |
Ala 275 | Val 275 | engineered mutation |
Ala 311 | Val 311 | engineered mutation |
Ala 415 | Leu 415 | engineered mutation |
Leu 538 | Gly 538 | engineered mutation |
Leu 602 | - | expression tag |
Val 603 | - | expression tag |
Pro 604 | - | expression tag |
Arg 605 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 112701.5 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1387.8 | |
All* | Total formula weight | 114089.3 |