8WGR

Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with antidepressant desipramine in KCl condition.

Summary for 8WGR

• Entry DOI: 10.2210/pdb8wgr/pdb
• Related: 8HFE 8HFF 8HFG
• EMDB information: 34718 34719 34720 37515
• Descriptor: Sodium-dependent noradrenaline transporter, 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: norepinephrine transporter, net, slc6a2, norepinephrine, dopamine, neurotransmitter, desipramine, bupropion, antidepressant., transport protein, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 69993.86

Authors

Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2023-09-22, release date: 2024-07-31, Last modification date: 2024-09-04)

• Primary citation: Tan, J.,Xiao, Y.,Kong, F.,Zhang, X.,Xu, H.,Zhu, A.,Liu, Y.,Lei, J.,Tian, B.,Yuan, Y.,Yan, C.; Molecular basis of human noradrenaline transporter reuptake and inhibition.; Nature, 632:921-929, 2024; PubMed: 39048818; DOI: 10.1038/s41586-024-07719-z

Experimental method

ELECTRON MICROSCOPY (2.75 Å)