8WGR
Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with antidepressant desipramine in KCl condition.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent noradrenaline transporter | polymer | 617 | 69386.5 | 1 | UniProt (P23975) Pfam (PF00209) | Homo sapiens (human) | Norepinephrine transporter,NET,Solute carrier family 6 member 2 |
| 2 | B, C (A) | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE | non-polymer | 266.4 | 2 | Chemie (DSM) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | E (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | F (A) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 69386.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 607.3 | |
| All* | Total formula weight | 69993.9 |
