8WGX

Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with norepinephrine in nanodisc.

Summary for 8WGX

Entry DOI	10.2210/pdb8wgx/pdb
Related	8HFE 8HFF 8HFG
EMDB information	34718 34719 34720 34721 37520
Descriptor	Sodium-dependent noradrenaline transporter, L-NOREPINEPHRINE (2 entities in total)
Functional Keywords	norepinephrine transporter, net, slc6a2, norepinephrine, dopamine, neurotransmitter, desipramine, bupropion, antidepressant., transport protein, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	69724.90
Authors	Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2023-09-22, release date: 2024-07-31)
Primary citation	Tan, J.,Xiao, Y.,Kong, F.,Zhang, X.,Xu, H.,Zhu, A.,Liu, Y.,Lei, J.,Tian, J.,Yuan, Y.,Yan, C. Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 2024 Cited by DOI: 10.1038/s41586-024-07719-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.47 Å)

Structure validation