8I3V

Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom.

Summary for 8I3V

• Entry DOI: 10.2210/pdb8i3v/pdb
• Related: 8HFE 8HFF 8HFG 8HFI 8HFL
• EMDB information: 35157
• Descriptor: Sodium-dependent noradrenaline transporter, (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: norepinephrine, net, escitalopram, inward-open, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 69746.39

Authors

Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2023-01-18, release date: 2024-07-03, Last modification date: 2024-08-07)

• Primary citation: Tan, J.,Xiao, Y.,Kong, F.,Zhang, X.,Xu, H.,Zhu, A.,Liu, Y.,Lei, J.,Tian, B.,Yuan, Y.,Yan, C.; Molecular basis of human noradrenaline transporter reuptake and inhibition.; Nature, 2024; PubMed: 39048818; DOI: 10.1038/s41586-024-07719-z

Experimental method

ELECTRON MICROSCOPY (2.85 Å)