8HFL

Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom.

Summary for 8HFL

Entry DOI	10.2210/pdb8hfl/pdb
Related	8HFE 8HFF 8HFG 8HFI
EMDB information	34718 34719 34720 34721 34722
Descriptor	Sodium-dependent noradrenaline transporter, Bupropion, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	norepinephrine transporter, net, slc6a2, norepinephrine, dopamine, neurotransmitter, desipramine, bupropion, antidepressant., transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	69661.74
Authors	Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2022-11-11, release date: 2024-05-15, Last modification date: 2024-09-04)
Primary citation	Tan, J.,Xiao, Y.,Kong, F.,Zhang, X.,Xu, H.,Zhu, A.,Liu, Y.,Lei, J.,Tian, B.,Yuan, Y.,Yan, C. Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632:921-929, 2024 Cited by PubMed: 39048818 DOI: 10.1038/s41586-024-07719-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation