8HFL

Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom.

Summary for 8HFL

• Entry DOI: 10.2210/pdb8hfl/pdb
• Related: 8HFE 8HFF 8HFG 8HFI
• EMDB information: 34718 34719 34720 34721 34722
• Descriptor: Sodium-dependent noradrenaline transporter, Bupropion, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: norepinephrine transporter, net, slc6a2, norepinephrine, dopamine, neurotransmitter, desipramine, bupropion, antidepressant., transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 69661.74

Authors

Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2022-11-11, release date: 2024-05-15)

• Primary citation: Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C.; Molecular basis for the reuptake and inhibition of human norepinephrine transporter; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3 Å)