2KS9
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SOLUTION CONFORMATION OF SUBSTANCE P IN WATER COMPLEXED WITH NK1R
Descriptor:Substance-P receptor, Substance P
Authors:Gayen, A., Mukhopadhyay, C.
Deposit date:2009-12-31
Release date:2010-11-03
Last modified:2010-11-17
Method:SOLUTION NMR
Cite:NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Biochim.Biophys.Acta, 2010
2KSA
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SUBSTANCE P IN DMPC/CHAPS ISOTROPIC Q=0.25 BICELLES AS A LIGAND FOR NK1R
Descriptor:Substance-P receptor, Substance P
Authors:Gayen, A., Mukhopadhyay, C.
Deposit date:2009-12-31
Release date:2010-11-03
Last modified:2010-11-17
Method:SOLUTION NMR
Cite:NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Biochim.Biophys.Acta, 2010
2KSB
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SUBSTANCE P IN ISOTROPIC Q=0.25 DMPC/CHAPS/GM1 BICELLES AS A LIGAND FOR NK1R
Descriptor:Substance-P receptor, Substance P
Authors:Gayen, A., Mukhopadhyay, C.
Deposit date:2009-12-31
Release date:2010-11-03
Last modified:2010-11-17
Method:SOLUTION NMR
Cite:NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Biochim.Biophys.Acta, 2010
2LNL
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STRUCTURE OF HUMAN CXCR1 IN PHOSPHOLIPID BILAYERS
Descriptor:C-X-C chemokine receptor type 1
Authors:Park, S., Das, B.B., Casagrande, F., Nothnagel, H., Chu, M., Kiefer, H., Maier, K., De Angelis, A., Marassi, F.M., Opella, S.J.
Deposit date:2011-12-31
Release date:2012-10-17
Last modified:2016-04-27
Method:SOLID-STATE NMR
Cite:Structure of the chemokine receptor CXCR1 in phospholipid bilayers.
Nature, 491, 2012
2R4R
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENOCEPTOR
Descriptor:Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, light chain, antibody for beta2 adrenoceptor, heavy chain
Authors:Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K.
Deposit date:2007-08-31
Release date:2007-11-06
Last modified:2011-02-09
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
2R4S
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CRYSTAL STRUCTURE OF THE HUMAN BETA2 ADRENOCEPTOR
Descriptor:Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, light chain, antibody for beta2 adrenoceptor, heavy chain
Authors:Rasmussen, S.G.F., Choi, H.J., Rosenbaum, D.M., Kobilka, T.S., Thian, F.S., Edwards, P.C., Burghammer, M., Ratnala, V.R., Sanishvili, R., Fischetti, R.F., Schertler, G.F., Weis, W.I., Kobilka, B.K.
Deposit date:2007-08-31
Release date:2007-11-06
Last modified:2011-02-09
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
2YDO
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH ADENOSINE BOUND
Descriptor:ADENOSINE RECEPTOR A2A
Authors:Lebon, G., Warne, T., Edwards, P.C., Bennett, K., Langmead, C.J., Leslie, A.G.W., Tate, C.G.
Deposit date:2011-03-23
Release date:2011-05-18
Last modified:2011-06-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
2YDV
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH NECA BOUND
Descriptor:ADENOSINE RECEPTOR A2A
Authors:Lebon, G., Warne, T., Edwards, P.C., Bennett, K., Langmead, C.J., Leslie, A.G.W., Tate, C.G.
Deposit date:2011-03-24
Release date:2011-05-18
Last modified:2011-06-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
2ZIY
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CRYSTAL STRUCTURE OF SQUID RHODOPSIN
Descriptor:Rhodopsin
Authors:Miyano, M., Shimamura, T.
Deposit date:2008-02-27
Release date:2008-05-06
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region
J.Biol.Chem., 283, 2008
3KJ6
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CRYSTAL STRUCTURE OF A METHYLATED BETA2 ADRENERGIC RECEPTOR-FAB COMPLEX
Descriptor:Beta-2 adrenergic receptor, Fab light chain, Fab heavy chain
Authors:Bokoch, M.P., Zou, Y., Rasmussen, S.G.F., Liu, C.W., Nygaard, R., Rosenbaum, D.M., Fung, J.J., Choi, H.-J., Thian, F.S., Kobilka, T.S., Puglisi, J.D., Weis, W.I., Pardo, L., Prosser, S., Mueller, L., Kobilka, B.K.
Deposit date:2009-11-02
Release date:2010-02-16
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
Nature, 463, 2010
3PBL
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STRUCTURE OF THE HUMAN DOPAMINE D3 RECEPTOR IN COMPLEX WITH ETICLOPRIDE
Descriptor:D(3) dopamine receptor
Authors:Chien, E.Y.T., Liu, W., Han, G.W., Katritch, V., Zhao, Q., Cherezov, V., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-10-20
Release date:2010-11-03
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of the human dopamine d3 receptor in complex with a d2/d3 selective antagonist.
Science, 330, 2010
3PDS
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IRREVERSIBLE AGONIST-BETA2 ADRENOCEPTOR COMPLEX
Descriptor:Fusion protein Beta-2 adrenergic receptor/Lysozyme (E.C.3.2.1.17)
Authors:Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K.
Deposit date:2010-10-24
Release date:2011-01-12
Last modified:2011-02-09
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
3PWH
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THERMOSTABILISED ADENOSINE A2A RECEPTOR
Descriptor:Adenosine receptor A2a
Authors:Dore, A.S., Robertson, N., Errey, J.C., Ng, I., Tehan, B., Hurrell, E., Magnani, F., Tate, C.G., Weir, M., Marshall, F.H.
Deposit date:2010-12-08
Release date:2011-09-07
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (3.296 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
3REY
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THERMOSTABILISED ADENOSINE A2A RECEPTOR IN COMPLEX WITH XAC
Descriptor:Adenosine receptor A2a
Authors:Dore, A.S., Robertson, N., Errey, J.C., Ng, I., Hollenstein, K., Tehan, B., Hurrell, E., Bennett, K., Congreve, M., Magnani, F., Tate, C.G., Weir, M., Marshall, F.H.
Deposit date:2011-04-05
Release date:2011-09-07
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (3.309 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
3RFM
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THERMOSTABILISED ADENOSINE A2A RECEPTOR IN COMPLEX WITH CAFFEINE
Descriptor:Adenosine receptor A2a
Authors:Dore, A.S., Robertson, N., Errey, J.C., Ng, I., Hollenstein, K., Tehan, B., Hurrell, E., Bennett, K., Congreve, M., Magnani, F., Tate, C.G., Weir, M., Marshall, F.H.
Deposit date:2011-04-06
Release date:2011-09-07
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
3UZA
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THERMOSTABILISED ADENOSINE A2A RECEPTOR IN COMPLEX WITH 6-(2,6-DIMETHYLPYRIDIN-4-YL)-5-PHENYL-1,2,4-TRIAZIN-3-AMINE
Descriptor:Adenosine receptor A2a
Authors:Congreve, M., Andrews, S.P., Dore, A.S., Hollenstein, K., Hurrell, E., Langmead, C.J., Mason, J.S., Ng, I.W., Tehan, B., Zhukov, A., Weir, M., Marshall, F.H.
Deposit date:2011-12-07
Release date:2012-03-21
Method:X-RAY DIFFRACTION (3.273 Å)
Cite:Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55, 2012
3UZC
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THERMOSTABILISED ADENOSINE A2A RECEPTOR IN COMPLEX WITH 4-(3-AMINO-5-PHENYL-1,2,4-TRIAZIN-6-YL)-2-CHLOROPHENOL
Descriptor:Adenosine A2A Receptor
Authors:Congreve, M., Andrews, S.P., Dore, A.S., Hollenstein, K., Hurrell, E., Langmead, C.J., Mason, J.S., Ng, I.W., Zhukov, A., Weir, M., Marshall, F.H.
Deposit date:2011-12-07
Release date:2012-03-21
Method:X-RAY DIFFRACTION (3.341 Å)
Cite:Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55, 2012
3VG9
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CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR WITH AN ALLOSTERIC INVERSE-AGONIST ANTIBODY AT 2.7 A RESOLUTION
Descriptor:Adenosine receptor A2a, antibody fab fragment light chain, antibody fab fragment heavy chain
Authors:Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T.
Deposit date:2011-08-04
Release date:2012-02-01
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Nature, 482, 2012
3VGA
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CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR WITH AN ALLOSTERIC INVERSE-AGONIST ANTIBODY AT 3.1 A RESOLUTION
Descriptor:Adenosine receptor A2a, antibody fab fragment light chain, antibody fab fragment heavy chain
Authors:Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T.
Deposit date:2011-08-04
Release date:2012-02-01
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Nature, 482, 2012
4EIY
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CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF A2AAR-BRIL IN COMPLEX WITH ZM241385 AT 1.8A RESOLUTION
Descriptor:Adenosine receptor A2a/Soluble cytochrome b562 chimera
Authors:Liu, W., Chun, E., Thompson, A.A., Chubukov, P., Xu, F., Katritch, V., Han, G.W., Heitman, L.H., Ijzerman, A.P., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2012-04-06
Release date:2012-07-25
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for allosteric regulation of GPCRs by sodium ions.
Science, 337, 2012
4UG2
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH CGS21680 BOUND
Descriptor:THERMOSTABILISED HUMAN A2A RECEPTOR
Authors:Lebon, G., Edwards, P.C., Leslie, A.G.W., Tate, C.G.
Deposit date:2015-03-21
Release date:2015-04-08
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
4UHR
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THERMOSTABILISED HUMAN A2A RECEPTOR WITH CGS21680 BOUND
Descriptor:THERMOSTABILISED HUMAN A2A RECEPTOR
Authors:Lebon, G., Edwards, P.C., Leslie, A.G.W., Tate, C.G.
Deposit date:2015-03-25
Release date:2015-04-08
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
4WW3
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CRYSTAL STRUCTURE OF THE LUMI INTERMEDIATE OF SQUID RHODOPSIN
Descriptor:BOG
Authors:Murakami, M., Kouyama, T.
Deposit date:2014-11-10
Release date:2015-06-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic Study of the LUMI Intermediate of Squid Rhodopsin
Plos One, 10, 2015
4YAY
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XFEL STRUCTURE OF HUMAN ANGIOTENSIN RECEPTOR
Descriptor:human Angiotensin Receptor_Bril Chimera
Authors:Zhang, H., Unal, H., Gati, C., Han, G.W., Zatsepin, N.A., James, D., Wang, D., Nelson, G., Weierstall, U., Messerschmidt, M., Williams, G.J., Boutet, S., Yefanov, O.M., White, T.A., Liu, W., Ishchenko, A., Tirupula, K.C., Desnoyer, R., Sawaya, M.C., Xu, Q., Coe, J., Cornrad, C.E., Fromme, P., Stevens, R.C., Katritch, V., Karnik, S.S., Cherezov, V., GPCR Network (GPCR)
Deposit date:2015-02-18
Release date:2015-04-22
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.
Cell, 161, 2015
5C1M
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CRYSTAL STRUCTURE OF ACTIVE MU-OPIOID RECEPTOR BOUND TO THE AGONIST BU72
Descriptor:Mu-type opioid receptor, Nanobody 39
Authors:Huang, W.J., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kato, H.E., Livingston, K.E., Thorsen, T.S., Kling, R., Granier, S., Gmeiner, P., Husbands, S.M., Traynor, J.R., Weis, W.I., Steyaert, J., Dror, R.O., Kobilka, B.K.
Deposit date:2015-06-15
Release date:2015-08-05
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into mu-opioid receptor activation.
Nature, 524, 2015
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