3VG9

Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 2.7 A resolution

Summary for 3VG9

• Entry DOI: 10.2210/pdb3vg9/pdb
• Related: 3VGA
• Descriptor: Adenosine receptor A2a, antibody fab fragment light chain, antibody fab fragment heavy chain, ... (7 entities in total)
• Functional Keywords: 7 transmembrane receptor, signal transduction, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P29274
• Total number of polymer chains: 3
• Total formula weight: 86917.91

Authors

Hino, T.,Arakawa, T.,Iwanari, H.,Yurugi-Kobayashi, T.,Ikeda-Suno, C.,Nakada-Nakura, Y.,Kusano-Arai, O.,Weyand, S.,Shimamura, T.,Nomura, N.,Cameron, A.D.,Kobayashi, T.,Hamakubo, T.,Iwata, S.,Murata, T. (deposition date: 2011-08-04, release date: 2012-02-01, Last modification date: 2023-11-08)

• Primary citation: Hino, T.,Arakawa, T.,Iwanari, H.,Yurugi-Kobayashi, T.,Ikeda-Suno, C.,Nakada-Nakura, Y.,Kusano-Arai, O.,Weyand, S.,Shimamura, T.,Nomura, N.,Cameron, A.D.,Kobayashi, T.,Hamakubo, T.,Iwata, S.,Murata, T.; G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody; Nature, 482:237-240, 2012; PubMed: 22286059; DOI: 10.1038/nature10750

Experimental method

X-RAY DIFFRACTION (2.7 Å)