5LWE

Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon

Summary for 5LWE

DescriptorC-C chemokine receptor type 9, Vercirnon, OLEIC ACID, ... (6 entities in total)
Functional Keywordsmembrane protein
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane; Multi-pass membrane protein P51686
Total number of polymer chains2
Total molecular weight85145.27
Authors
Oswald, C.,Rappas, M.,Kean, J.,Dore, A.S.,Errey, J.C.,Bennett, K.,Deflorian, F.,Christopher, J.A.,Jazayeri, A.,Mason, J.S.,Congreve, M.,Cooke, R.M.,Marshall, F.H. (deposition date: 2016-09-16, release date: 2016-12-07, Last modification date: 2016-12-28)
Primary citation
Oswald, C.,Rappas, M.,Kean, J.,Dore, A.S.,Errey, J.C.,Bennett, K.,Deflorian, F.,Christopher, J.A.,Jazayeri, A.,Mason, J.S.,Congreve, M.,Cooke, R.M.,Marshall, F.H.
Intracellular allosteric antagonism of the CCR9 receptor.
Nature, 540:462-465, 2016
PubMed: 27926729 (PDB entries with the same primary citation)
DOI: 10.1038/nature20606
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244600.6%3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 5lwe
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Molmil generated image of 5lwe
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Molmil generated image of 5lwe
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5lwe.pdb1.gz [101.43 KB])
Coordinate files for Biological unit (5lwe.pdb2.gz [103.61 KB])