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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LWE

Crystal structure of the human CC chemokine receptor type 9 (CCR9) in complex with vercirnon

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004950	molecular_function	chemokine receptor activity
A	0006935	biological_process	chemotaxis
A	0006955	biological_process	immune response
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016493	molecular_function	C-C chemokine receptor activity
B	0004930	molecular_function	G protein-coupled receptor activity
B	0004950	molecular_function	chemokine receptor activity
B	0006935	biological_process	chemotaxis
B	0006955	biological_process	immune response
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0016493	molecular_function	C-C chemokine receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue 79K A 401

Chain	Residue
A	VAL69
A	VAL259
A	TYR317
A	GLY321
A	GLU322
A	ARG323
A	PHE324
A	ASP327
A	ARG78
A	THR81
A	THR83
A	ASP84
A	LEU87
A	ARG144
A	ALA255
A	THR256

site_id	AC2
Number of Residues	2
Details	binding site for residue OLA A 402

Chain	Residue
A	LEU265
A	OLA403

site_id	AC3
Number of Residues	3
Details	binding site for residue OLA A 403

Chain	Residue
A	HIS250
A	OLA402
A	OLA404

site_id	AC4
Number of Residues	8
Details	binding site for residue OLA A 404

Chain	Residue
A	TYR234
A	THR235
A	ILE238
A	LEU241
A	OLA403
B	HIS239
B	OLA404
B	OLA405

site_id	AC5
Number of Residues	2
Details	binding site for residue OLA A 405

Chain	Residue
A	TYR145
A	HIS239

site_id	AC6
Number of Residues	3
Details	binding site for residue OLA A 406

Chain	Residue
A	TRP74
A	LEU96
A	OLA408

site_id	AC7
Number of Residues	4
Details	binding site for residue OLA A 407

Chain	Residue
A	TRP56
A	PRO102
A	ILE106
B	PRO53

site_id	AC8
Number of Residues	5
Details	binding site for residue OLA A 408

Chain	Residue
A	LEU96
A	MET128
A	TRP173
A	OLA406
A	OLA413

site_id	AC9
Number of Residues	3
Details	binding site for residue OLA A 409

Chain	Residue
A	LEU64
A	OLA410
A	OLA415

site_id	AD1
Number of Residues	3
Details	binding site for residue OLA A 411

Chain	Residue
A	TYR164
A	MET167
B	MET167

site_id	AD2
Number of Residues	3
Details	binding site for residue OLA A 412

Chain	Residue
A	PHE319
A	OLA410
A	CLR417

site_id	AD3
Number of Residues	8
Details	binding site for residue OLA A 413

Chain	Residue
A	CYS169
A	PHE170
A	TRP173
A	ALA177
A	ALA178
A	ILE181
A	OLA408
B	ILE181

site_id	AD4
Number of Residues	3
Details	binding site for residue OLA A 414

Chain	Residue
A	ASP143
A	ARG161
B	TYR37

site_id	AD5
Number of Residues	2
Details	binding site for residue OLA A 415

Chain	Residue
A	ILE70
A	OLA409

site_id	AD6
Number of Residues	6
Details	binding site for residue OLA A 416

Chain	Residue
A	LEU68
A	LEU328
A	LEU335
A	GLY336
A	OLA410
B	ARG325

site_id	AD7
Number of Residues	2
Details	binding site for residue CLR A 417

Chain	Residue
A	PHE308
A	OLA412

site_id	AD8
Number of Residues	4
Details	binding site for residue MLI A 418

Chain	Residue
A	ARG144
A	ALA147
A	ARG161
A	ARG323

site_id	AD9
Number of Residues	17
Details	binding site for residue 79K B 401

Chain	Residue
B	VAL69
B	ARG78
B	THR81
B	THR83
B	ASP84
B	LEU87
B	ARG144
B	ALA252
B	ALA255
B	THR256
B	VAL259
B	TYR317
B	GLY321
B	GLU322
B	ARG323
B	PHE324
B	ASP327

site_id	AE1
Number of Residues	1
Details	binding site for residue OLA B 402

Chain	Residue
B	LYS254

site_id	AE2
Number of Residues	8
Details	binding site for residue OLA B 403

Chain	Residue
B	VAL262
B	LEU265
B	SER266
B	OLA404
B	HIS250
B	LYS254
B	THR258
B	THR261

site_id	AE3
Number of Residues	6
Details	binding site for residue OLA B 404

Chain	Residue
A	OLA404
B	TYR234
B	HIS250
B	ILE257
B	OLA403
B	OLA405

site_id	AE4
Number of Residues	4
Details	binding site for residue OLA B 405

Chain	Residue
A	HIS239
A	OLA404
B	HIS250
B	OLA404

site_id	AE5
Number of Residues	6
Details	binding site for residue OLA B 406

Chain	Residue
B	PHE86
B	MET138
B	ASP143
B	ILE146
B	ARG161
B	LEU175

site_id	AE6
Number of Residues	4
Details	binding site for residue OLA B 407

Chain	Residue
B	TYR145
B	PHE227
B	THR235
B	OLA413

site_id	AE7
Number of Residues	2
Details	binding site for residue OLA B 408

Chain	Residue
B	PHE170
B	OLA409

site_id	AE8
Number of Residues	4
Details	binding site for residue OLA B 409

Chain	Residue
B	TRP74
B	MET85
B	ASN89
B	OLA408

site_id	AE9
Number of Residues	1
Details	binding site for residue OLA B 410

Chain	Residue
B	ILE92

site_id	AF1
Number of Residues	1
Details	binding site for residue OLA B 411

Chain	Residue
B	SER67

site_id	AF2
Number of Residues	1
Details	binding site for residue OLA B 413

Chain	Residue
B	OLA407

site_id	AF3
Number of Residues	5
Details	binding site for residue OLA B 414

Chain	Residue
A	PHE285
B	ILE279
B	ALA283
B	PHE285
B	VAL291

site_id	AF4
Number of Residues	3
Details	binding site for residue MLI B 415

Chain	Residue
B	ARG144
B	ALA147
B	ARG161

site_id	AF5
Number of Residues	9
Details	binding site for residues OLA A 410 and OLA B 412

Chain	Residue
A	LEU64
A	PHE319
A	PHE319
A	SER339
A	OLA409
A	OLA416
A	CLR417
B	LEU64
B	ILE92

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SCVlLIMCICVDRYIaI

Chain	Residue	Details
A	SER132-ILE148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	HIS49-TRP74
B	HIS49-TRP74

site_id	SWS_FT_FI2
Number of Residues	44
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	TYR75-MET85
A	ALA151-GLU159
A	ALA244-SER248
B	TYR75-MET85
B	ALA151-GLU159
B	ALA244-SER248

site_id	SWS_FT_FI3
Number of Residues	46
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	PHE86-ALA109
B	PHE86-ALA109

site_id	SWS_FT_FI4
Number of Residues	76
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	ASP110-LYS120
A	TYR186-THR208
A	MET284-ALA290
B	ASP110-LYS120
B	TYR186-THR208
B	MET284-ALA290

site_id	SWS_FT_FI5
Number of Residues	58
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	VAL121-GLN150
B	VAL121-GLN150

site_id	SWS_FT_FI6
Number of Residues	50
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	LYS160-LEU185
B	LYS160-LEU185

site_id	SWS_FT_FI7
Number of Residues	68
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	LYS209-GLN243
B	LYS209-GLN243

site_id	SWS_FT_FI8
Number of Residues	68
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	LYS249-ALA283
B	LYS249-ALA283

site_id	SWS_FT_FI9
Number of Residues	60
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:27926729

Chain	Residue	Details
A	VAL291-GLY321
B	VAL291-GLY321

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN32
B	ASN32

218853

PDB entries from 2024-04-24

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