PDB: 80 件ウェブページステータス検索Chemie searchBIRD

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4RXZ	Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide 分子名称: 12-MER PEPTIDE INHIBITOR, Protein Mdm4 著者 Pazgier, M, Gohain, N, Tolbert, W.D. 登録日 2014-12-12 公開日 2015-07-22 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene, 35, 2016
4N5T	The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041 分子名称: ATSP-7041 stapled-peptide, Protein Mdm4 著者 Graves, B.J, Lukacs, C, Janson, C.A. 登録日 2013-10-10 公開日 2013-11-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc.Natl.Acad.Sci.USA, 110, 2013
3LBJ	Structure of human MDMX protein in complex with a small molecule inhibitor 分子名称: N-[(3S)-1-({6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indol-2-yl}carbonyl)pyrrolidin-3-yl]-N,N',N'-trimethylpropane-1,3-diamine, Protein Mdm4, SULFATE ION 著者 Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. 登録日 2010-01-08 公開日 2010-03-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
2Z5S	Molecular basis for the inhibition of p53 by Mdmx 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. 登録日 2007-07-17 公開日 2007-11-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
2Z5T	Molecular basis for the inhibition of p53 by Mdmx 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. 登録日 2007-07-17 公開日 2007-11-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
3EQY	Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor 分子名称: 12-mer peptide inhibitor, GUANIDINE, Mdm4 protein, ... 著者 Pazgier, M, Lu, W. 登録日 2008-10-01 公開日 2009-03-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc.Natl.Acad.Sci.USA, 106, 2009
2VJF	Crystal Structure of the MDM2-MDMX RING Domain Heterodimer 分子名称: CITRATE ANION, E3 UBIQUITIN-PROTEIN LIGASE MDM2, MDM4 PROTEIN, ... 著者 Mace, P.D, Linke, K, Smith, C.A, Day, C.L. 登録日 2007-12-10 公開日 2008-05-13 最終更新日 2019-10-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the Mdm2/Mdmx Ring Domain Heterodimer Reveals Dimerization is Required for Their Ubiquitylation in Trans. Cell Death Differ., 15, 2008
2VJE	Crystal Structure of the MDM2-MDMX RING Domain Heterodimer 分子名称: CITRATE ANION, E3 UBIQUITIN-PROTEIN LIGASE MDM2, MDM4 PROTEIN, ... 著者 Mace, P.D, Linke, K, Smith, C.A, Day, C.L. 登録日 2007-12-10 公開日 2008-05-13 最終更新日 2018-06-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ., 15, 2008
3FDO	Structure of human MDMX in complex with high affinity peptide 分子名称: MAGNESIUM ION, Protein Mdm4, Synthetic high affinity peptide 著者 Czarna, A.L, Popowicz, G.M, Holak, T.A. 登録日 2008-11-26 公開日 2008-12-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle, 8, 2009
3DAC	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Holak, T.A. 登録日 2008-05-29 公開日 2008-09-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle, 7, 2008
3DAB	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Holak, T.A. 登録日 2008-05-29 公開日 2008-09-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle, 7, 2008
3JZQ	Human MDMX liganded with a 12mer peptide inhibitor (pDIQ) 分子名称: Protein Mdm4, SULFATE ION, pDIQ peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-24 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
3JZP	Human MDMX liganded with a 12mer peptide inhibitor (pDI6W) 分子名称: POTASSIUM ION, Protein Mdm4, pDI6W peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-24 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
3JZO	Human MDMX liganded with a 12mer peptide (pDI) 分子名称: POTASSIUM ION, Protein Mdm4, pDI peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-23 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
3U15	Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443 分子名称: (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, Protein Mdm4, SULFATE ION 著者 Lukacs, C.M, Janson, C.A, Graves, B.J. 登録日 2011-09-29 公開日 2012-06-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc.Natl.Acad.Sci.USA, 109, 2012
7KJN	CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA) 分子名称: D-PMI-omega, Protein Mdm4 著者 Tolbert, W.D, Pazgier, M. 登録日 2020-10-26 公開日 2021-11-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA) To Be Published
3VBG	Structure of hDM2 with Dimer Inducing Indolyl Hydantoin RO-2443 分子名称: (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, E3 ubiquitin-protein ligase Mdm2 著者 Lukacs, C.M, Janson, C.A, Graves, B.J. 登録日 2012-01-02 公開日 2012-06-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc.Natl.Acad.Sci.USA, 109, 2012
5J7F	Structure of MDM2 with low molecular weight inhibitor with aliphatic linker. 分子名称: 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid, E3 ubiquitin-protein ligase Mdm2 著者 Twarda-Clapa, A, Kubica, K, Guzik, K, Dubin, G, Holak, T.A. 登録日 2016-04-06 公開日 2017-05-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J. Med. Chem., 60, 2017
5J7G	Structure of MDM2 with low molecular weight inhibitor with aliphatic linker. 分子名称: 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid, E3 ubiquitin-protein ligase Mdm2 著者 Twarda-Clapa, A, Kubica, K, Guzik, K, Dubin, G, Holak, T.A. 登録日 2016-04-06 公開日 2017-05-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J. Med. Chem., 60, 2017
8IA5	Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, 9-mer peptide, ... 著者 Cheng, X.Y, Wei, Q.Y, Huang, Y, Su, Z.D. 登録日 2023-02-07 公開日 2023-02-22 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX To Be Published
7EL4	The crystal structure of p53p peptide fragment in complex with the N-terminal domain of MdmX 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Cellular tumor antigen p53,Protein Mdm4, MAGNESIUM ION 著者 Cheng, X.Y, Zhang, B.L, Li, Z.C, Kuang, Z.K, Su, Z.D. 登録日 2021-04-08 公開日 2021-06-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 The crystal structure of the N-terminal domain of MdmX in complex with p53p peptide fragment To Be Published
3EQS	Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor 分子名称: 12-mer peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, GUANIDINE 著者 Pazgier, M, Lu, W. 登録日 2008-10-01 公開日 2009-03-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc.Natl.Acad.Sci.USA, 106, 2009
7C44	Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4 著者 Cheng, X.Y, Zhang, B.L, Kuang, Z.K, Yang, J, Li, Z.C, Yu, J.P, Zhao, Z.T, Cao, C.Z, Su, Z.D. 登録日 2020-05-15 公開日 2020-06-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a To Be Published
7C3Q	Human MdmX protein in complex with Nutlin3a 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, DI(HYDROXYETHYL)ETHER, ... 著者 Su, Z.D, Cheng, X.Y, Zhang, B.L, Kuang, Z.K, Yang, J, Li, Z.C, Yu, J.P, Zhao, Z.T, Cao, C.Z. 登録日 2020-05-13 公開日 2020-06-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Human MdmX protein in complex with Nutlin3a To Be Published
7C3Y	Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a 分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4 著者 Su, Z.D, Cheng, X.Y, Zhang, B.L, Kuang, Z.K, Yang, J, Li, Z.C, Yu, J.P, Zhao, Z.T, Cao, C.Z. 登録日 2020-05-14 公開日 2020-06-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.632 Å) 主引用文献 Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a To Be Published

 

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