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5J7G

Structure of MDM2 with low molecular weight inhibitor with aliphatic linker.

Summary for 5J7G
Entry DOI10.2210/pdb5j7g/pdb
DescriptorE3 ubiquitin-protein ligase Mdm2, 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid (3 entities in total)
Functional Keywordsp53, mdm2, mdmx, protein-protein interaction, cancer, inhibitor, ligase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains4
Total formula weight53036.13
Authors
Twarda-Clapa, A.,Kubica, K.,Guzik, K.,Dubin, G.,Holak, T.A. (deposition date: 2016-04-06, release date: 2017-05-17, Last modification date: 2024-01-10)
Primary citationTwarda-Clapa, A.,Krzanik, S.,Kubica, K.,Guzik, K.,Labuzek, B.,Neochoritis, C.G.,Khoury, K.,Kowalska, K.,Czub, M.,Dubin, G.,Domling, A.,Skalniak, L.,Holak, T.A.
1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.
J. Med. Chem., 60:4234-4244, 2017
Cited by
PubMed: 28482147
DOI: 10.1021/acs.jmedchem.7b00104
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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