5J7G
Structure of MDM2 with low molecular weight inhibitor with aliphatic linker.
Summary for 5J7G
Entry DOI | 10.2210/pdb5j7g/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid (3 entities in total) |
Functional Keywords | p53, mdm2, mdmx, protein-protein interaction, cancer, inhibitor, ligase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 4 |
Total formula weight | 53036.13 |
Authors | Twarda-Clapa, A.,Kubica, K.,Guzik, K.,Dubin, G.,Holak, T.A. (deposition date: 2016-04-06, release date: 2017-05-17, Last modification date: 2024-01-10) |
Primary citation | Twarda-Clapa, A.,Krzanik, S.,Kubica, K.,Guzik, K.,Labuzek, B.,Neochoritis, C.G.,Khoury, K.,Kowalska, K.,Czub, M.,Dubin, G.,Domling, A.,Skalniak, L.,Holak, T.A. 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J. Med. Chem., 60:4234-4244, 2017 Cited by PubMed: 28482147DOI: 10.1021/acs.jmedchem.7b00104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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