Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7BU7
DownloadVisualize
BU of 7bu7 by Molmil
Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9
Descriptor: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, ...
Authors:Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X.
Deposit date:2020-04-04
Release date:2020-12-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.
Cell Res., 31, 2021
8J6Q
DownloadVisualize
BU of 8j6q by Molmil
Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex
Descriptor: (3R)-3-hydroxybutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, ...
Authors:Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y.
Deposit date:2023-04-26
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Orthosteric and allosteric modulation of human HCAR2 signaling complex.
Nat Commun, 14, 2023
8THK
DownloadVisualize
BU of 8thk by Molmil
Cryo-EM structure of A61603-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein
Descriptor: Endolysin,Alpha-1A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Su, M, Huang, X.Y.
Deposit date:2023-07-17
Release date:2023-08-16
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of agonist specificity of alpha 1A -adrenergic receptor.
Nat Commun, 14, 2023
8J24
DownloadVisualize
BU of 8j24 by Molmil
Cryo-EM structure of FFAR2 complex bound with acetic acid
Descriptor: ACETATE ION, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tai, L, Li, F, Tang, W, Sun, X, Wang, J.
Deposit date:2023-04-14
Release date:2024-01-24
Last modified:2024-04-10
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.
Cell Res., 34, 2024
8W88
DownloadVisualize
BU of 8w88 by Molmil
Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex
Descriptor: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F.
Deposit date:2023-09-01
Release date:2023-11-22
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Recognition of methamphetamine and other amines by trace amine receptor TAAR1.
Nature, 624, 2023
5WF5
DownloadVisualize
BU of 5wf5 by Molmil
Agonist bound human A2a adenosine receptor with D52N mutation at 2.60 A resolution
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Human A2a adenosine receptor T4L chimera
Authors:White, K.L, Eddy, M.T, Gao, Z, Han, G.W, Hanson, M.A, Lian, T, Deary, A, Patel, N, Jacobson, K.A, Katritch, V, Stevens, R.C.
Deposit date:2017-07-11
Release date:2018-02-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.
Structure, 26, 2018
1L9H
DownloadVisualize
BU of 1l9h by Molmil
Crystal structure of bovine rhodopsin at 2.6 angstroms RESOLUTION
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
Authors:Okada, T, Fujiyoshi, Y, Silow, M, Navarro, J, Landau, E.M, Shichida, Y.
Deposit date:2002-03-23
Release date:2002-05-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 99, 2002
7DW9
DownloadVisualize
BU of 7dw9 by Molmil
Cryo-EM structure of human V2 vasopressin receptor in complex with an Gs protein
Descriptor: CHOLESTEROL, CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhou, F, Jiang, Y.
Deposit date:2021-01-15
Release date:2021-07-21
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular basis of ligand recognition and activation of human V2 vasopressin receptor.
Cell Res., 31, 2021
4UHR
DownloadVisualize
BU of 4uhr by Molmil
Thermostabilised HUMAN A2a Receptor with CGS21680 bound
Descriptor: 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, THERMOSTABILISED HUMAN A2A RECEPTOR
Authors:Lebon, G, Edwards, P.C, Leslie, A.G.W, Tate, C.G.
Deposit date:2015-03-25
Release date:2015-04-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
2YDV
DownloadVisualize
BU of 2ydv by Molmil
Thermostabilised HUMAN A2a Receptor with NECA bound
Descriptor: ADENOSINE RECEPTOR A2A, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, octyl 1-thio-beta-D-glucopyranoside
Authors:Lebon, G, Warne, T, Edwards, P.C, Bennett, K, Langmead, C.J, Leslie, A.G.W, Tate, C.G.
Deposit date:2011-03-24
Release date:2011-05-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
4UG2
DownloadVisualize
BU of 4ug2 by Molmil
Thermostabilised HUMAN A2a Receptor with CGS21680 bound
Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, THERMOSTABILISED HUMAN A2A RECEPTOR
Authors:Lebon, G, Edwards, P.C, Leslie, A.G.W, Tate, C.G.
Deposit date:2015-03-21
Release date:2015-04-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
6TPN
DownloadVisualize
BU of 6tpn by Molmil
Crystal structure of the Orexin-2 receptor in complex with HTL6641 at 2.61 A resolution
Descriptor: 2-(5,6-dimethoxypyridin-3-yl)-1,1-bis(oxidanylidene)-4-[[2,4,6-tris(fluoranyl)phenyl]methyl]pyrido[2,3-e][1,2,4]thiadiazin-3-one, NITRATE ION, OLEIC ACID, ...
Authors:Rappas, M, Ali, A, Bennett, K.A, Brown, J.D, Bucknell, S.J, Congreve, M, Cooke, R.M, Cseke, G, de Graaf, C, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Mason, J.S, Mould, R, Patel, J.C, Tehan, B.G, Weir, M, Christopher, J.A.
Deposit date:2019-12-13
Release date:2020-01-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.608 Å)
Cite:Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
J.Med.Chem., 63, 2020
8DZR
DownloadVisualize
BU of 8dzr by Molmil
GR89,696 bound Kappa Opioid Receptor in complex with gustducin
Descriptor: G alpha gustducin protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Fay, J.F, Che, T.
Deposit date:2022-08-08
Release date:2023-05-03
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Ligand and G-protein selectivity in the kappa-opioid receptor.
Nature, 617, 2023
7M8W
DownloadVisualize
BU of 7m8w by Molmil
XFEL crystal structure of the prostaglandin D2 receptor CRTH2 in complex with 15R-methyl-PGD2
Descriptor: 15R-methyl-prostaglandin D2, CITRATE ANION, Prostaglandin D2 receptor 2, ...
Authors:Shiriaeva, A, Han, G.W, Cherezov, V.
Deposit date:2021-03-30
Release date:2021-08-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Molecular basis for lipid recognition by the prostaglandin D 2 receptor CRTH2.
Proc.Natl.Acad.Sci.USA, 118, 2021
8FYX
DownloadVisualize
BU of 8fyx by Molmil
Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Descriptor: Buspirone, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D.
Deposit date:2023-01-26
Release date:2024-05-15
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.62 Å)
Cite:Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024
6FK7
DownloadVisualize
BU of 6fk7 by Molmil
Crystal structure of N2C/D282C stabilized opsin bound to RS06
Descriptor: (2~{R},3~{R})-2-(4-chlorophenyl)-3-oxidanyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one, PALMITIC ACID, Rhodopsin, ...
Authors:Mattle, D, Standfuss, J, Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4NTJ
DownloadVisualize
BU of 4ntj by Molmil
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ...
Authors:Zhang, K, Zhang, J, Gao, Z.-G, Zhang, D, Zhu, L, Han, G.W, Moss, S.M, Paoletta, S, Kiselev, E, Lu, W, Fenalti, G, Zhang, W, Muller, C.E, Yang, H, Jiang, H, Cherezov, V, Katritch, V, Jacobson, K.A, Stevens, R.C, Wu, B, Zhao, Q, GPCR Network (GPCR)
Deposit date:2013-12-02
Release date:2014-03-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Nature, 509, 2014
6FK9
DownloadVisualize
BU of 6fk9 by Molmil
Crystal structure of N2C/D282C stabilized opsin bound to RS09
Descriptor: (2~{S})-3-methyl-2-phenyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one, PALMITIC ACID, Rhodopsin, ...
Authors:Mattle, D, Standfuss, J, Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8XJK
DownloadVisualize
BU of 8xjk by Molmil
Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Descriptor: (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ...
Authors:Zhang, X, Li, X, Liu, G, Gong, W.
Deposit date:2023-12-21
Release date:2024-02-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.63 Å)
Cite:Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
6ZIN
DownloadVisualize
BU of 6zin by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692
Descriptor: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence
Authors:Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
Deposit date:2020-06-26
Release date:2021-02-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.639 Å)
Cite:Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
8FYT
DownloadVisualize
BU of 8fyt by Molmil
LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Descriptor: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D.
Deposit date:2023-01-26
Release date:2024-05-15
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024
8G59
DownloadVisualize
BU of 8g59 by Molmil
Cryo-EM structure of the TUG891 bound GPR120-Giq complex
Descriptor: 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J.
Deposit date:2023-02-12
Release date:2023-03-08
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
3C9L
DownloadVisualize
BU of 3c9l by Molmil
Structure of ground-state bovine rhodospin in a hexagonal crystal form
Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ACETYL GROUP, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Stenkamp, R.E.
Deposit date:2008-02-16
Release date:2008-08-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.646 Å)
Cite:Alternative models for two crystal structures of bovine rhodopsin.
Acta Crystallogr.,Sect.D, 64, 2008
8DZS
DownloadVisualize
BU of 8dzs by Molmil
GR89,696 bound Kappa Opioid Receptor in complex with Gz
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(z) subunit alpha, ...
Authors:Fay, J.F, Che, T.
Deposit date:2022-08-08
Release date:2023-05-03
Last modified:2023-05-24
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Ligand and G-protein selectivity in the kappa-opioid receptor.
Nature, 617, 2023
4J4Q
DownloadVisualize
BU of 4j4q by Molmil
Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside
Descriptor: ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ...
Authors:Park, J.H, Morizumi, T, Li, Y, Hong, J.E, Pai, E.F, Hofmann, K.P, Choe, H.W, Ernst, O.P.
Deposit date:2013-02-07
Release date:2013-10-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Opsin, a structural model for olfactory receptors?
Angew.Chem.Int.Ed.Engl., 52, 2013

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon